Health Problems of Civilization
eISSN: 2354-0265
ISSN: 2353-6942
Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
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abstract:
Original paper

COLLAGEN DEPOSITION IN SMOOTH MUSCLES OF URETEROPELVIC JUNCTION OBSTRUCTION IN CHILDREN

Qadir Mohammed Salih Qadir
1
,
Kamiran Jalalaldin Sadeeq
1
,
Nareen Arif Abdulrahman
2
,
Ayoub Abid Abdulmajeed
3
,
Azad Abduljabar Haleem
4

  1. Department of Surgery, College of Medicine, University of Duhok, Iraqi Kurdistan, Iraq
  2. Department of Community and Family Medicine, College of Medicine, University of Duhok, Iraqi Kurdistan, Iraq
  3. Department of Pediatrics, College of Nursery, University of Duhok, Iraqi Kurdistan, Iraq
  4. Department of Pediatrics, College of Medicine, University of Duhok, Iraqi Kurdistan, Iraq
Health Prob Civil
DOI: https://doi.org/10.5114/hpc.2025.147772
Online publish date: 2025/03/19
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Background
Ureteropelvic junction obstruction (UPJO) is the most common pathological cause of antenatal and neonatal hydronephrosis. In this study we evaluated the proportion of collagen deposition to smooth muscles of obstructed ureteropelvic junction and its relation to the age at the time of diagnosis and to the postoperative complications.

Material and methods
Fifty-five patients diagnosed antenatally or postnatally with idiopathic UPJO were recruited for the study. The age ranged from 1 month to 12 years. All the patients underwent the Anderson and Hynes pyeloplasty and biopsy samples were sent for histopathological examination and collagen assessment.

Results
The median age of enrolled patients was 38.9 (1-144) months. Male to female ratio was 2.1:1. 65.5% patients had UPJO on the left side while 23.6% patients was right-sided and remaining 10.9% cases were bilateral. A significant association was found between collagen deposition and age at diagnosis. No significant relation was demonstrated between collagen deposition and postoperative complications.

Conclusions
Based on the finding, it could be recommended that management for UPJO should be concentrated at an early age without any delay taking into account the clinical perspectives of various management techniques for the pediatric populations to avoid further complications.

keywords:

Anderson and Hynes pyeloplasty, ureteropelvic junction obstruction, collagen-muscle ratio, postoperative complications, hydronephrosis

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