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Health Problems of Civilization
eISSN: 2354-0265
ISSN: 2353-6942
Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
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Original paper

CORRELATION BETWEEN HBSAG QUANTITATIVE ASSAY RESULTS AND HBV-DNA LEVELS IN CHRONIC HEPATITIS B PATIENTS: A SINGLE-CENTER EXPERIENCE

Zhivka Stoykova
1
,
Tsvetelina Kostadinova
2, 3
,
Teodora Katrandzhieva
1, 2
,
Irina Ivanova
2, 4
,
Tatina Todorova
1, 2

  1. Department of Microbiology and Virology, Medical University of Varna, Bulgaria
  2. University Hospital ”St. Marina”, Varna, Bulgaria
  3. Medical College, Medical University of Varna, Bulgaria
  4. Department of Internal Medicine, Medical University of Varna, Bulgaria
Health Problems of Civilization
Online publish date: 2025/06/10
Article file
- Todorova et al (2).pdf  [0.41 MB]
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1. World Health Organization. Global Hepatitis Report 2024. [Internet]. Geneva: WHO; 2024 [access 2025 Feb 20]. Available from: https://www.who.int/publications/i/item/9789240091672
2. Jeng WJ, Papatheodoridis GV, Lok ASF. Hepatitis B. Lancet. 2023; 401: 1039-52. https://doi.org/10.1016/S0140-6736(22)01468-4
3. Yardeni D, Chang KM, Ghany MG. Current best practice in hepatitis B management and understanding long-term prospects for cure. Gastroenterology. 2023; 164: 42-60.e6. https://doi.org/10.1053/j.gastro.2022.10.008
4. Bivegete S, McNaughton AL, Trickey A, Thornton Z, Scanlan B, Lim AG, et al. Estimates of hepatitis B virus prevalence among general population and key risk groups in EU/EEA/UK countries: a systematic review. Eurosurveillance. 2023; 28: 2200738. https://doi.org/10.2807/1560-7917.ES.2023.28.30.2200738
5. Kevorkyan A, Teoharov P, Lernout T, Petrova N, Raycheva R, Ivanov I, et al. Prevalence of HBV and HCV among outpatients in the Plovdiv region of Bulgaria, 2010-2011. J Med Virol. 2015; 87: 401-6. https://doi.org/10.1002/jmv.24065
6. Gotseva A, Naseva E. Prevalence of hepatitis B in random bulgarian blood samples – a single-site experience. Acta Medica Bulg. 2023; 50: 5-9. https://doi.org/10.2478/amb-2023-0013
7. CDC. Hepatitis B, acute and chronic 2024 case definition [Internet]. Atlanta: US Centers Dis Control Prev; 2024 [access 2025 Mar 2]. Available from: https://ndc.services.cdc.gov/case-definitions/hepatitis-b-acute-and-chronic-2024/
8. Chan HLY, Thompson A, Martinot-Peignoux M, Piratvisuth T, Cornberg M, Brunetto MR, et al. Hepatitis B surface antigen quantification: Why and how to use it in 2011 – a core group report. J Hepatol. 2011; 55: 1121-31. https://doi.org/10.1016/j.jhep.2011.06.006
9. Insani Nirmala VF, Aryati A, Susianti H, Mustika S. Correlation between quantitative hepatitis B surface antigen and hepatitis B virus deoxyribonucleic acid levels in hepatitis B e antigen-positive and hepatitis B e antigen-negative chronic hepatitis B patients. Turk J Gastroenterol. 2023; 34: 378-82. https://doi.org/10.5152/tjg.2020.19612
10. Maimunah U, Wardhani P, Wungu CDK, Rahmanda AF, Kurniawan AA, Palayukan A. Correlation between quantitative HBsAg and quantitative HBV DNA in chronic hepatitis B patients: a systematic review and meta-analysis. Egypt Liver J. 2024; 14: 1-11. https://doi.org/10.1186/s43066-024-00336-5
11. zu Siederdissen CH, Cornberg M. The role of HBsAg levels in the current management of chronic HBV infection. Ann Gastroenterol. 2014; 27: 105.
12. Wang C, Pan YC, Jia ZF, Chi XM, Wang YQ, Yang N, et al. The relationship between hepatitis B virus serum DNA, RNA and quantitative hepatitis B surface antigen, and the predictive value for mother-to-child transmission: an observational cohort study. BJOG An Int J Obstet Gynaecol. 2022; 129: 241-7. https://doi.org/10.1111/1471-0528.16884
13. Hadziyannis SJ. Natural history of chronic hepatitis B in Euro-Mediterranean and African countries. J Hepatol. 2011; 55: 183-91. https://doi.org/10.1016/j.jhep.2010.12.030
14. Ciccozzi M, Babakir-Mina M, Lo Presti A, Salpini R, Cella E, Gabanelli E, et al. Molecular analysis of hepatitis B virus in Bulgaria. J Med Virol. 2013; 85: 49-54. https://doi.org/10.1002/jmv.23432
15. Naoumov N, Schneider R, Grötzinger T, Jung MC, Miska S, Pape GR, et al. Precore mutant hepatitis B virus infection and liver disease. Gastroenterology. 1992; 102: 538-43. https://doi.org/10.1016/0016-5085(92)90101-4
16. Lampertico P, Agarwal K, Berg T, Buti M, Janssen HLA, Papatheodoridis G, et al. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017; 67: 370-98. https://doi.org/10.1016/j.jhep.2017.03.021
17. Sonneveld MJ, Hansen BE, Piratvisuth T, Jia JD, Zeuzem S, Gane E, et al. Response-guided peginterferon therapy in hepatitis B e antigen-positive chronic hepatitis B using serum hepatitis B surface antigen levels. Hepatology. 2013; 58: 872-80. https://doi.org/10.1002/hep.26436
18. World Health Organization. WHO guidelines on hepatitis B and C testing. [Internet]. Geneva: WHO; 2017 [access 2025 Mar 10]. Available from: https://www.who.int/publications/i/item/9789241549981
19. World Health Organization. Guidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection. [Internet]. Geneva: WHO; 2024 [access 2025 Mar 10]. Available from: https://www.who.int/publications/i/item/9789240090903
20. Nguyen HH, Lee SS. Fluctuating hepatitis B viremia: full of sound and fury, signifying nothing?. Saudi J Gastroenterol. 2022; 28: 319. https://doi.org/10.4103/sjg.sjg_307_22
21. Chtourou A, Gargouri S, Elleuch E, Feki L, Smaoui F, Taktak A, et al. Large spontaneous HBV DNA fluctuations and potential usefulness of a single-point measurement of combined HBV DNA and quantitative HBsAg for the exclusion of HBeAg-negative chronic hepatitis B: a prospective Tunisian cohort study. Arab J Gastroenterol. 2023; 24: 223-9. https://doi.org/10.1016/j.ajg.2023.09.002
22. Brunetto MR, Oliveri F, Colombatto P, Moriconi F, Ciccorossi P, Coco B, et al. Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers. Gastroenterology. 2010; 139: 483-90. https://doi.org/10.1053/j.gastro.2010.04.052
Copyright: © 2025 Pope John Paul II State School of Higher Education in Biała Podlaska. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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