Abstract
2/2015
vol. 66
Case report
Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling
Pol J Pathol 2015; 66 (2): 195-199
Online publish date: 2015/07/28
Extracardiac rhabdomyomas (RM) are very rare benign tumors with a poorly understood pathogenesis. In this report we describe two RM cases – a sublingual adult type tumor and a genital type tumor involving the uterine cervix. The patho-clinical characteristics, as well as the pioneer immunohistochemical analysis of ERK1/2 and AKT/mTOR pathway status is included. The expression of key proteins involved in above signaling gives new insight into the biology of extracardiac RM.
Keywords
rhabdomyoma, cellular signaling, AKT/mTOR, extracardiac
Integrated with
