Folia Neuropathologica
eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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3/2025
vol. 63
 
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Case report

Cerebellar lesions caused by vitamin B12 deficiency: a case report

Xin Hu
1
,
Hong Xu
1
,
Yang Han
1
,
Yan Wu
1
,
Li Fang
1
,
Li-Na Qin
1
,
Hong Miao
1
,
Li Chen
1
,
Ju-Ping Chen
1

  1. Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, China
Folia Neuropathol 2025; 63 (3): 320-326
Online publish date: 2025/08/11
Article file
- Cerebellar.pdf  [0.16 MB]
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1. Ahn TB, Cho JW, Jeon BS. Unusual neurological presentations of vitamin B(12) deficiency. Eur J Neurol 2004; 11: 339-341.
2. Allen LH, Miller JW, de Groot L, Rosenberg IH, Smith AD, Ref-sum H, Raiten DJ. Biomarkers of Nutrition for Development (BOND): Vitamin B-12 review. J Nutr 2018; 148 (suppl 4): 1995S-2027S.
3. Allen LH. Vitamin B-12. Adv Nutr 2012; 3: 54-55.
4. Andres E, Serraj K. Optimal management of pernicious anemia. J Blood Med 2012; 3: 97-103.
5. Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull 2008; 29 (2 Suppl): S126-S131.
6. Bottiglieri T. Homocysteine, vitamin B12, and folic acid in major depressive disorder. Am J Psychiatry 2013; 156: 426-428.
7. Calderón-Ospina CA, Nava-Mesa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther 2020; 26: 5-13.
8. Golding J, Gregory S, Clark R, Iles-Caven Y, Ellis G, Taylor CM, Hibbeln J. Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood. Nutr Res 2021; 86: 68-78.
9. Gräsbeck R. Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria). Orphanet J Rare Dis 2006; 1: 17.
10. He W, Dong WY, Liu F, Chen QM. Mechanism of cerebellum changes in a vitamin B12 deficiency patient. Stroke Nerv Dis 2014; 21: 229-231.
11. Katsaros VK, Glocker FX, Hemmer B, Schumacher M. MRI of spinal cord and brain lesions in subacute combined degeneration. Neuroradiology 1998; 40: 716-719.
12. Li FY, Gao ZZ, Zhang HJ. Cerebellar ataxia due to vitamin B12 deficiency: a case report (with MRI changes). Chinese J Coal Ind Med 2011; 14: 470-471.
13. Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003; 26: 137-146.
14. Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull 2008; 29 (2 Suppl): S101-S115.
15. Morita S, Miwa H, Kihira T, Kondo T. Cerebellar ataxia and leukoencephalopathy associated with cobalamin deficiency. J Neurol Sci 2003; 216: 183-184.
16. Pawlak R, Parrott SJ, Raj S, Cullum-Dugan D, Lucus D. How prevalent is vitamin B(12) deficiency among vegetarians? Nutr Rev 2013; 71: 110-117.
17. Ray JG, Wyatt PR, Thompson MD, Vermeulen MJ, Meier C, Wong PY, Farrell SA, Cole DEC. Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population. Epidemiology 2007; 18: 362-366.
18. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol 2006; 5: 949-960.
19. Salinas M, Flores E, López-Garrigós M, Leiva-Salinas C. Vitamin B12 deficiency and clinical laboratory: Lessons revisited and clarified in seven questions. Int J Lab Hematol 2018; 40 Suppl 1: 83-88.
20. Scalabrino G, Buccellato FR, Veber D, Mutti E. New basis of the neurotrophic action of vitamin B12. Clin Chem Lab Med 2003; 41: 1435-1437.
21. Scalabrino G, Peracchi M. New insights into the pathophysiology of cobalamin deficiency. Trends Mol Med 2006; 12: 247-254.
22. Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol 2015; 4: 180-183.
23. Solomon LR. Functional cobalamin (vitamin B12) deficiency: role of advanced age and disorders associated with increased oxidative stress. Eur J Clin Nutr 2015; 69: 687-692.
24. Sourander A, Silwal S, Upadhyaya S, Surcel HM, Hinkka-Yli-Salomäki S, McKeague IW, Cheslack-Postava K, Brown AS. Maternal serum Vitamin B12 and offspring attention-deficit/hyperactivity disorder (ADHD). Eur Child Adolesc Psychiatry 2021; 30: 1449-1462.
25. Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med 2013; 368: 149-160.
26. Sukumar N, Rafnsson SB, Kandala NB, Bhopal R, Yajnik CS, Saravanan P. Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis [published correction appears in Am J Clin Nutr. 2017 Jan;105(1):241]. Am J Clin Nutr 2016; 103: 1232-1251.
27. Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr 2015; 69: 1-2.
28. Tursi A, Brandimarte G, Giorgetti G. High prevalence of small intestinal bacterial overgrowth in celiac patients with persistence of gastrointestinal symptoms after gluten withdrawal. Am J Gastroenterol 2003; 98: 839-843.
29. Valuck RJ, Ruscin JM. A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults. J Clin Epidemiol 2004; 57: 422-428.
30. Wong CW. Vitamin B12 deficiency in the elderly: is it worth screening? Hong Kong Med J 2015; 21: 155-164.
Copyright: © 2025 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
 
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