eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3-4/2006
vol. 31
 
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abstract:

Clinical immunology
The assessment of caspase activation during apoptosis of malignant cells in B-cell chronic lymphocytic leukaemia

Monika Podhorecka
,
Anna Dmoszynska

Centr Eur J Immunol 2006; 31 (3-4): 84-86
Online publish date: 2007/01/16
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In this study we analysed caspase activation in peripheral blood and bone marrow cells of B-cell chronic lymphocytic leukaemia (B-CLL) exposed to apoptosis both spontaneous and induced via external and internal pathway. We used the method based on detection of activated caspases with FAM-VAD-FMK that is the fluorochrome labelled inhibitor of caspases and flow cytometry technique. We detected the higher rate of apoptosis induced by mitochondrial way in comparison to receptor one that may suggest dominance of this mechanism in B-CLL. We also observed the higher rate of spontaneous and mitochondrial-induced apoptosis in peripheral blood in comparison to bone marrow indicating the differences in apoptosis process depending on cell environment.
keywords:

B-CLL, apoptosis, caspases

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