eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
2/2012
vol. 63
 
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abstract:

Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer

Cheng-Jeng Tai
,
Chun-Chao Chang
,
Ming-Chung Jiang
,
Chung-Min Yeh
,
Tzu-Cheng Su
,
Pei-Ru Wu
,
Chih-Jung Chen
,
Kun-Tu Yeh
,
Shu-Hui Lin
,
Hung-Chang Chen

POL J PATHOL 2012; 2: 93-100
Online publish date: 2012/08/03
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The Ras-ERK pathway is frequently up-regulated in colorectal cancer. We analyzed the clinical-pathological correlation of K-Ras mutation and phospho-ERK expression in colorectal cancer. K-Ras mutations were detected in only 32.5% (41/126) of the colorectal cancer cases, while all cancers were positive for phospho-ERK staining. Colorectal cancer with wild-typeK-Ras and low phospho-ERK expression had a significantly higher survival rate (log-rank P = 0.04). There were 9 cases of K-Ras mutation/low phospho-ERK diseases; 88.9% (8/9) of them were stage III/IV diseases. High phospho-ERK expression was associated with a high stage and T status of the cancer, yet combined K-Ras mutation/phospho-ERK expression analysis further increased the efficiency of colorectal cancer prognosis. Our results demonstrate that Ras-ERK pathway correlated closely with colorectal cancer progression. Moreover, although colorectal cancer with K-Ras mutations has a more aggressive phenotype; the mutation rate is not very high. Phospho-ERK may be a useful marker in combination with K-Ras for improving the prognosis of colorectal cancer.
keywords:

colorectal cancer, ERK, mutation, phosphorylation, Ras

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