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ISSN: 1734-3402
Family Medicine & Primary Care Review
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vol. 20
Original paper

Clinical profile of ocular toxoplasmosis in the Universiti Sains Malaysia Hospital – 7-year review

Tong Jong Haw Matthew, Embong Zunaina, Adil Hussein, Ahmad Tajudin Liza-Sharmini, Wan Hitam Wan-Hazabbah, Ismail Shatriah

Family Medicine & Primary Care Review 2018; 20(1): 13–16
Online publish date: 2018/03/16
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Toxoplasmosis is caused by infection from a ubiquitous obligate intracellular parasite known as Toxoplasma gondii, which can infect both human and warm-blooded animals. This infection is commonly prevalent in developing country.

The purpose of this study is to report on a 7-year review of ocular toxoplasmosis patients that presented to the Universiti Sains Malaysia Hospital.

Material and methods
This is a retrospective review of cases. The demographic data, ocular manifestations, clinical and laboratory profiles, treatment and disease outcome were collected from the patients’ medical records from January 2010 to December 2016.

A total of 16 patients with a diagnosis of ocular toxoplasmosis were identified. The mean age was 43.2, with standard deviation ± 15.4 years old. The percentage was 62.5% (10 patients) females and 37.5% (6 patients) male. The majority of patients were Malay (93.4%, 15 patients). The most common classification of uveitis was panuveitis (56.3%, 9 patients), followed by posterior uveitis (25%, 4 patients), anterior uveitis (12.5%, 2 patients) and intermediate uveitis (6.2%, 1 patient). Keratic precipitate (75%, 12 patients) and vitritis (75%, 12 patients) were the most common ocular manifestation of ocular toxoplasmosis. A serological test for toxoplasmosis found only 1 patient with positive serum immunoglobulin M, while all patients displayed non-reactive serum immunoglobulin G (except 1 missing data). All ocular toxoplasmosis patients were treated with oral Azithromycin 500 mg daily for 6 weeks, 81.3% (13 patients) were given an instillation of a steroid eye drop, while 25% (4 patients) required administration of an oral steroid. All of the patients responded well to treatment, but 25% (4 patients) suffered from recurrence, which required a second course of treatment.

Ocular toxoplasmosis is a serious and depilating disease that can cause serious ocular morbidities. This review shows a diverse presentation of ocular toxoplasmosis as a result of toxoplasmosis infection.


toxoplasmosis, uveitis, retinitis, vitritis

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