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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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Original paper

Clinical significance of umbilical region involvement in pemphigus vulgaris in a series of 81 ethnic Poles: a comparative analysis of the distribution of lesions in two infrequent locations

Magdalena Jałowska
1
,
Justyna Gornowicz-Porowska
1, 2
,
Agnieszka Seraszek-Jaros
3
,
Monika Bowszyc-Dmochowska
4
,
Elżbieta Kaczmarek
3
,
Marian Dmochowski
1

1.
Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
2.
Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medical Sciences, Poznan, Poland
3.
Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, Poznan, Poland
4.
Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
Adv Dermatol Allergol 2022; XXXIX (2): 281-285
Online publish date: 2021/01/20
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Introduction

Pemphigus diseases are relatively rare, but form a potentially life-threatening group of autoimmune blistering dermatoses (ABD) in which immunoglobulin G (IgG) antibodies target desmosomal proteins to produce intraepithelial, mucocutaneous blistering. Diagnosis relies on a combination of clinical features as well as the direct immunofluorescence of perilesional tissue and serum testing with molecular-biochemical techniques for auto­antibodies to desmogleins [1]. The pemphigus group presents chronic evolution, with significant mortality and an important impairment in quality of life. Characteristic skin lesions of pemphigus mainly are located at the transition between the epithelium/extra-residual epidermis and the follicular epithelium – the scalp; trunk anterior and posterior seborrheic areas, as well as in places of transition between the epidermis and stratified squamous epithelium of mucous membranes – around natural body orifices [2]. It is also suggested that the skin appendages (hair follicles, eccrine glands, nail apparatus) are affected by processes occurring in the course of pemphigus diseases [2]. It is believed that the nail involvement in pemphigus vulgaris (PV) is uncommon; however, literature data indicate the presence of lesions there in up to 22–30% of PV patients [3]. The temporal relationship with the occurrence of nail lesions in PV varies: it may be a part of the primary manifestation, accompany a relapse, or be a harbinger of its exacerbation. Moreover, it is suggested that the appearance of haemorrhagic nail eruptions in the course of PV, related to the severity of the disease, may be useful in the prognostic assessment of the patient’s condition [4]. It is also interesting that nail apparatus involvement may be the only indicator of the disease process at the beginning of PV. The study of photographic archives from 2002–2017 in ethnic Poles conducted in a setting of a Central European university dermatology department and assessing exclusively nail apparatus changes showed that such lesions were present in just 13.4% of PV patients, namely they were less frequent than in other ethnicities [4].
The umbilicus (navel, belly button) is a scar on the abdomen caused by the removal of the umbilical cord from the newborn baby. It is the central relatively weak depression of the anterior abdominal wall opposite the disk between L3–L4 vertebrae or L4 vertebra [5]. It is an important aesthetic component of the body. Its abnormal appearance or absence may cause distress, may even be a source of grief and depression. Across cultures umbilicus has been not only a sign of youth and beauty, but also the source of sexual arousal epitomized by belly dancing. Extraordinarily, the comprehensive survey of belly-button lint conducted by Kruszelnicki of the University of Sydney, won the Ig Nobel Prize for Interdisciplinary Research [6]. Navel stones can even form there. The first known use of the word navel was before the 12th century [7]. The word is often used in telling collocations, such as the navel of the world, navel-gazing. As such, an aesthetically pleasing umbilicus is regarded as necessary for an attractive abdomen. Navel fetishism or belly button fetishism is a partialism in which an individual is attracted to the human navel. In the 1960s or 1970s navel piercings have become quite common in Western societies in order to draw attention to the navel.
Umbilical lesions are rare but always require detailed diagnostics to rule out hidden malignancy [8] and should be diagnosed on careful clinical examination and histopa­thological evaluation. In some cases, the direct immunofluorescence (DIF) examination is of key importance. Umbilical lesions as a clinical manifestation of pemphigus have been reported very rarely so far, but already in the textbook of Grzybowski titled “Skin Diseases for Doctors and Students” from 1948, the navel was indicated as an important site of involvement in pemphigus vegetans (PVEG) [9]. The navel area as one of the predilection sites in PVEG is also described in the Japanese dermatological textbook for medical students [10]. Recognition of this presentation is relevant. The differential diagnosis should be made with pyogenic granuloma, erythema multiforme, psoriasis, impetigo, intestinal fistulae and metastatic nodules and others. Possible explanation for the presence of pemphigus lesions in umbilicus include expression of altered antigens, linked with embryonic structures such as the umbilical cord that would stimulate IgG autoimmunity against desmogleins [11].

Aims

The aim of this study was to analyse the involvement of the umbilical region in PV in ethnic Poles and compare frequency of occurrence of pemphigus skin lesions located in the navel area and nail apparatus.

Material and methods

The study was conducted in a setting of a Central European university dermatology department. Eighty one Slavic patients (50 females and 31 males, female to male ratio = 1.61) with diseases of the PV group having IgG antibodies to DSG3 or both DSG3 and DSG1 were retrospectively analysed for the presence of umbilical and nail apparatus pemphigus lesions using photographic archives from 2002–2020. The study group consisted of 57 patients with mucocutaneous PV (MCPV), 17 with mucosal dominant PV (MPV), 3 patients with cutaneous PV (CPV), and 4 with PVEG. The age of the patients with pemphigus ranged from 31 to 90 years. The mean age was 59 years. The diagnoses were based on the combination of clinical data, and DIF of perilesional tissue also for evaluation of IgG4 deposits (Fig. 1) having dew drops on spider web appearance [12] and IgG1 deposits, as well as mono-analyte ELISA with DSG1/3 (Euroimmun, Germany or MBL, Japan) or multi-analyte ELISA with envoplakin, type VII collagen, DSG1, DSG3, BP180, BP230 (Euro­immun, Germany) corroborated by the histopathological H+E examination.

Data processing and statistical analysis

Statistical analysis was performed using STATISTICA, version 13 (StatSoft, Inc., Tulsa, OK, USA). Statistical significance was  = 0.05. A result was deemed statistically significant if p < . The difference test between two proportions was used to check the difference between the percentage of PV patients with navel area involvement and nail apparatus involvement.

Results

The nail apparatus involvement was found in 10 of 81 PV patients (12.3%). Skin lesions in the navel area were present in 12 of 81 PV patients (14.8%) and their assessment, limited by our study design involving an analysis of just photographic files, was described here. Only females (10 with MCPV, 1 with MPV and 1 with PVEG) had lesions in the navel area (Fig. 1). There was no significant difference between PV patients with nail apparatus involvement and navel area involvement (p = 0.4632). One young female patient with MPV presented with just a single cutaneous lesion in the umbilical region, and the biopsy for DIF was taken from that area. Initially, the patient had erosions on the oral mucosa, and neither the patient nor the family practitioner were aware that it is the same disease. One middle-aged female patient with MCPV exhibited lesions both around the navel and in the nail apparatus.

Discussion

Skin lesions around the umbilical region always require a detailed differential diagnosis. Differentiation should take into account not only infectious diseases, neoplastic diseases, inflammatory diseases including psoriasis, allergic diseases and others, but also autoimmune bullous diseases. In the case of lesions in the navel area, it is extremely rare to think of blistering diseases, pregnant/lactating females are the exception. In pemphigoid gestationis (PG), skin lesions typically develop on the abdomen. Blisters characteristically occur in the umbilical region and later spread to the rest of the body. The first immune response in PG occurs within the placenta because placental trophoblasts and amniochorionic stromal cells show an abnormal expression of major histocompatibility complex (MHC) class II antigen [13]. It is striking that only females with PV had lesions in the navel area in our study. This observation may be just fortuitous as our study was designed to analyse retrospectively photographic archives merely in a single tertiary referral centre, but we are tempted to speculate that the causal relationship may exist between the female reproductive system and the pattern of expression of PV lesions around the umbilicus. The microchimerism may underlie this connection. Those assumptions require further analysis ideally on different series of PV patients using a multicentre approach. Some publications state that the umbilical area is a predilection site for patients with a “classical” variety of bullous pemphigoid (BP) [14]. Schmidt et al. described BP with the skin lesions limited only to the umbilical region [15]. Sometimes lesions in this cutaneous location may appear initially in ABD and therefore the umbilical area is diagnostically valuable. This peculiar presentation in pemphigus, not yet completely elucidated, has been rarely reported in the literature. Umbilical region involvement in patients with pemphigus was assessed in a limited study totalling just 10 patients [16]. A possible explanation may be the presence of either novel epitopes or an association with embryonic or scar tissue located in the umbilical-cord region [16]. Erythema, erosions, crusts and vegetating skin lesions were the main clinical features of pemphigus of the umbilical region. Such skin lesions around the navel most often suggest a nickel-related allergic contact dermatitis (ACD). The development of an itchy eczematous eruption near the umbilicus is almost pathognomonic for contact dermatitis to nickel. There are two reports in the literature which suggest that nickel can induce pemphigus-type lesions [17, 18]. Th17 lymphocytes which are involved in the pathogenesis of both ACD and pemphigus may be responsible for this process. Indications for involvement of Th17 in human skin allergy were reported for the first time by detection of IL-17 mRNA in skin lesions from nickel allergic patients and in skin-derived nickel specific T cells [19]. In several human studies, T-cell-clones could be isolated from ecze­ma biopsies, and high IL-17 levels were observed after challenge with an allergen [19]. A crucial role of Th17 in ACD is recruitment of neutrophils, activation of fibrocytes and macrophages. The indications for the participation of Th17 in the development of ACD are supported by data from IL-17 deficient mice with reduced contact hypersensitivity reactions that could be restored after transplantation of wild type CD4+T cells [20]. Also PV patients had higher serum levels of inflammatory Th1/Th17 cytokines (IFN-
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