eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2018
vol. 69
 
Share:
Share:
more
 
 
abstract:
Original paper

Clinicopathologic study of 10 cases of gastric adenocarcinoma with hepatoid or enteroblastic differentiation

Naoto Kuroda, Kenji Yorita

Pol J Pathol 2018; 69 (2): 128-135
Online publish date: 2018/07/06
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Gastric adenocarcinoma with hepatoid or enteroblastic differentiation (GAHED), known also as AFP-producing carcinoma, is a rare neoplasm. Ten cases with GAHED and 209 cases without GAHED were selected. Clinicopathological features of GAHED were investigated. The disease-free survival (DFS) of the GAHED group was compared with that of the non-GAHED group. Grossly, the tumours consisted of two early types and eight advanced types. Histologically, all tumours were composed of various proportions of tubular, cribriform, papillary, solid, and/or trabecular growth patterns of clear to slightly eosinophilic tumour cells. Hyaline globules were observed in all tumours. AFP and Hep-Par1 were immunoreactive in all tumours. In fluorescence in situ hybridisation of HER2 gene/chromosome 17, the amplification of HER2 gene was observed in two cases that showed positive reaction for HER2 protein. Clinical follow-up was available in nine cases. Regarding the clinical outcome, 3 and 6 patients were alive without disease and alive with disease, respectively. In a statistical analysis, the DFS of the GAHED group was significantly worse than that of the non-GAHED group.

GAHED is morphologically characterised by various growth patterns of clear to slightly eosinophilic tumour cells and intracytoplasmic possession of hyaline globules. This tumour may have the potential to behave in an aggressive clinical fashion.
keywords:

stomach, hepatoid, enteroblastic, clinicopathological study, differentiation, adenocarcinoma

references:
Ishikura H, Fukasawa Y, Ogasawara K, et al. An AFP-producing gastric carcinoma with features of hepatic differentiation. Cancer 1985; 56: 840-848.
Ishikura H. Kirimoto K, Shamoto M, et al. Hepatoid adenocarcinoma of stomach. Cancer 1986; 58: 119-126.
Ishikura H, Kishimoto T, Andachi H, et al. Gastrointestinal hepatoid adenocarcinoma: venous permeation and mimicry of hepatocellular carcinoma, a report of four cases. Histopathology 1997; 31: 47-54.
Kishimoto T, Nagai Y, Kato K, et al. Hepatoid adenocarcinoma: a new clinicopathological entity and the hypothesis on carcinogenesis. Med Electron Microsc 2000; 33: 57-63.
Matsunou H, Konishi F, Jalal RE, et al. Alpha-fetoprotein-producing gastric carcinoma with enteroblastic differentiation. Cancer 1994; 73: 534-540.
Motoyama T, Aizawa K, Watanabe H, et al. Alpha-fetoprotein-producing gastric carcinomas: a comparative study of three different subtypes. Acta Pathol Jpn 1993; 43: 654-661.
Su JS, Chen YT, Wang RC, et al. Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review. World J Gastroenterol 2013; 19: 321-327.
Roberts CC, Colby TV, Batts KP. Carcinoma of the stomach with hepatocyte differentiation (hepatoid adenocarcinoma). Mayo Clin Proc 1997; 72: 1154-1160.
Ushiku T, Shiozaki A, Shibahara J, et al. SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol 2010; 34: 533-540.
Gálvez-Muñoz E, Gallego-Plazas J, Gonzalez-Orozco V, et al. Hepatoid adenocarcinoma of the stomach- a different histology for not so different gastric adenocarcinoma: a case report. Int Sem Surg Oncol 2009l; 6: 13.
Murakami T, Yao T, Mitomi H, et al. Clinicopathological and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases. Gastric Cancer 2016; 19: 498-507.
deLorimier A, Park F, Aranha GV, et al. Hepatoid carcinoma of stomach. Cancer 1993; 71: 293-296.
Matsumoto K, Ueyama H, Matsumoto K, et al. Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation. World J Gastroenterol 2016; 22: 8203-8210.
Yang J, Wang R, Zhang W, et al. Clinicopathological and prognostic characteristics of hepatoid adenocarcinoma of the stomach. Gastroenterol Res Pract 2014; 2014: 140587.
Kinjo T, Taniguchi H, Kushima R, et al. Histologic and immunohistochemical analyses of alpha-fetoprotein-producing cancer of the stomach. Am J Surg Pathol 2012; 36: 56-65.
Hwang SW, Lee SJ, Park PE, et al. Gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation. Basic Appl Pathol 2012; 5: 22-25.
Deng Y, Chen X, Ye Y, et al. Histological characterization and prognostic evaluation of 62 gastric neuroendocrine carcinomas. Contemp Oncol (Pozn) 2016; 20: 311-319.
FEATURED PRODUCTS
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe