Folia Neuropathologica
eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
2/2025
vol. 63
 
Share:
Send email
Share:
Case report

Clinicopathological and neuroradiological presentation in an immuno-deficiency patient with central nervous system recurrence of Burkitt lymphoma: an extremely rare case with complete remission achieved twice after GMALL-B-ALL/NHL2002 and R-MIV protocols

Piotr Glinka
1
,
Michał Sobstyl
1
,
Grzegorz Rymkiewicz
2
,
Karol Karamon
3
,
Monika Skowronek-Płachta
3
,
Albert Acewicz
4
,
Katarzyna Błachnio
2
,
Robert Konecki
5
,
Marcin Chmielewski
2

  1. Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland
  2. Flow Cytometry Laboratory, Department of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
  3. Department of Radiology, Institute of Psychiatry and Neurology, Warsaw, Poland
  4. Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
  5. Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
Folia Neuropathol 2025; 63 (2): 198-208
DOI: https://doi.org/10.5114/fn.2025.152574
Online publish date: 2025/07/04
Article file
- Clinicopathological (1).pdf  [0.47 MB]
Get citation
 
PlumX metrics:
 
1. Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Barreto de Oliveira I, Berti AE, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia 2022; 36: 1720-1748.
2. Atallah-Yunes SA, Murphy DJ, Noy A. HIV-associated Burkitt lymphoma. Lancet Haematol 2020; 7: e594-e600.
3. Bowden SG, Munger DN, Thiessen J, Woll SCS, Han SJ, Neuwelt EA, Barajas RF, Ambady P. The clinical heterogeneity of entirely nonenhancing CNS lymphoma: a case series. CNS Oncol 2021; 10: CNS67.
4. Cordone I, Masi S, Carosi M, Vidiri A, Marchesi F, Marino M, Telera S, Pasquale A, Mengarelli A, Conti L, Pescarmona E, Pace A, Carapella CM. Brain stereotactic biopsy flow cytometry for central nervous system lymphoma characterization: advantages and pitfalls. J Exp Clin Cancer Res 2016; 35: 128.
5. Dunleavy K, Little RF, Wilson WH. Update on Burkitt lymphoma. Hematol Oncol Clin North Am 2016; 30: 1333-1343.
6. Ferry JA. Burkitt’s lymphoma: clinicopathologic features and differential diagnosis. Oncologist 2006; 11: 375-383.
7. Kasamon YL, Brodsky RA, Borowitz MJ, Ambinder RF, Crilley PA, Cho SY, Tsai H, Smith BD, Gladstone DE, Carraway HE, Huff CA, Matsui WH, Bolaños-Meade J, Jones RJ, Swinnen LJ. Brief intensive therapy for older adults with newly diagnosed Burkitt or atypical Burkitt lymphoma/leukemia. Leuk Lymphoma 2013; 54: 483-490.
8. Khan A, Brahim A, Ruiz M, Nagovski N. Relapsed/refractory Burkitt lymphoma and HIV infection. Int J STD AIDS 2018; 29: 695-703.
9. Kwok HM, Li KY, Chan RLS, Chan CH, Wong SKH, Lee CM, Cheng LF, Ma JKF. Different facets of intracranial central nervous system lymphoma and its imaging mimics. J Clin Imaging Sci 2022; 12: 4.
10. Linch DC. Burkitt lymphoma in adults. Br J Haematol 2012; 156: 693-703.
11. Malikova H, Burghardtova M, Koubska E, Mandys V, Kozak T, Weichet J. Secondary central nervous system lymphoma: spectrum of morphological MRI appearances. Neuropsychiatr Dis Treat 2018; 14: 733-740.
12. Meister A, Hentrich M, Wyen C, Hübel K. Malignant lymphoma in the HIV-positive patient. Eur J Haematol 2018; 101: 119-126.
13. Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S. Burkitt’s lymphoma. Lancet 2012 ; 379: 1234-1244.
14. Morell AA, Shah AH, Cavallo C, Eichberg DG, Sarkiss CA, Benveniste R, Ivan ME, Komotar RJ. Diagnosis of primary central nervous system lymphoma: a systematic review of the utility of CSF screening and the role of early brain biopsy. Neurooncol Pract 2019; 6: 415-423.
15. Pons-Escoda A, Naval-Baudin P, Velasco R, Vidal N, Majós C. Imaging of Lymphomas Involving the CNS: an update-review of the full spectrum of disease with an emphasis on the World Health Organization classifications of CNS tumors 2021 and hematolymphoid tumors 2022. AJNR Am J Neuroradiol 2023; 44: 358-366.
16. Ribrag V, Koscielny S, Bosq J, Leguay T, Casasnovas O, Fornecker LM, Recher C, Ghesquieres H, Morschhauser F, Girault S, Le Gouill S, Ojeda-Uribe M, Mariette C, Cornillon J, Cartron G, Verge V, Chassagne-Clément C, Dombret H, Coiffier B, Lamy T, Tilly H, Salles G. Rituximab and dose-dense chemotherapy for adults with Burkitt’s lymphoma: a randomised, controlled, open-label, phase 3 trial. Lancet 2016; 387: 2402-2411.
17. Rodrigo JA, Hicks LK, Cheung MC, Song KW, Ezzat H, Leger CS, Boro J, Montaner JS, Harris M, Leitch HA. HIV-associated Burkitt lymphoma: good efficacy and tolerance of intensive chemotherapy including CODOX-M/IVAC with or without rituximab in the HAART era. Adv Hematol 2012; 2012: 735392.
18. Ruzinova MB, Caron T, Rodig SJ. Altered subcellular localization of c-Myc protein identifies aggressive B-cell lymphomas harboring a c-MYC translocation. Am J Surg Pathol 2010; 34: 882-891.
19. Rymkiewicz G, Grygalewicz B, Chechlinska M, Blachnio K, Bystydzienski Z, Romejko-Jarosinska J, Woroniecka R, Zajdel M, Domanska-Czyz K, Martin-Garcia D, Nadeu F, Swoboda P, Rygier J, Pienkowska-Grela B, Siwicki JK, Prochorec-Sobieszek M, Salaverria I, Siebert R, Walewski J. A comprehensive flow-cytometry-based immunophenotypic characterization of Burkitt-like lymphoma with 11q aberration. Mod Pathol 2018; 31: 732-743.
20. Sakarou M, Eisele L, Dührsen U, Hüttmann A. Efficacy of the GMALL-B-ALL/NHL2002 protocol in Burkitt leukemia/lymphoma and aggressive non-Hodgkin-lymphomas with or without CNS involvement. Eur J Haematol 2019; 102: 241-250.
21. Short NJ, Kantarjian HM, Ko H, Khoury JD, Ravandi F, Thomas DA, Garcia-Manero G, Khouri M, Cortes JE, Wierda WG, Verstovsek S, Estrov Z, Ferrajoli A, Thompson PA, Pierce S, O’Brien SM, Jabbour E. Outcomes of adults with relapsed or refractory Burkitt and high-grade B-cell leukemia/lymphoma. Am J Hematol 2017; 92: E114-E117.
22. Szumera-Ciećkiewicz A, Rymkiewicz G, Grygalewicz B, Jesionek-Kupnicka D, Gruchała A, Ziarkiewicz-Wróblewska B, Gałązka K, Reszeć J, Borg K, Prochorec-Sobieszek M. Comprehensive histopathological diagnostics of aggressive B-cell lymphomas based on the updated criteria of the World Health Organisation’s 2017 classification. Pol J Pathol 2018; 69: 1-19.
23. Woroniecka R, Rymkiewicz G, Szafron LM, Blachnio K, Szafron LA, Bystydzienski Z, Pienkowska-Grela B, Borkowska K, Rygier J, Kotyl A, Malawska N, Wojtkowska K, Parada J, Borysiuk A, Murcia Pienkowski V, Rydzanicz M, Grygalewicz B. Cryptic MYC insertions in Burkitt lymphoma: new data and a review of the literature. PLoS One 2022; 17: e0263980.
24. Zayac AS, Evens AM, Danilov A, Smith SD, Jagadeesh D, Leslie LA, et al. Outcomes of Burkitt lymphoma with central nervous system involvement: evidence from a large multicenter cohort study. Haematologica 2021; 106: 1932-1942.
Copyright: © 2025 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
  
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2025 Termedia Sp. z o.o.
Developed by Bentus.