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ISSN: 1233-9687
Polish Journal of Pathology
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vol. 74
Original paper

Clinicopathological significance of  Obg-like ATPase 1 and its association with Snail in gastric cancer

Juan Wang
Qinghua Cao
Zhiqing Wang

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Pol J Pathol 2023; 74 (1): 42-50
Online publish date: 2023/04/28
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Obg-like ATPase 1 (OLA1) is a member of the Obg family of P-loop NTPases and has recently been detected in several human cancer cells. However, its expression type and clinical relevance in gastric cancer remains unclear.

In the present study, mRNA level of OLA1 in gastric cancer (GC) was detected in 2 datasets downloaded from the open Gene Expression Omnibus database and 30 cancer tissues. Immunohistochemistry was performed on GC and its association with Snail in 334 GC patients.

The results showed that OLA1 mRNA and protein were elevated in GC tissues. High expression of OLA1 was significantly associated with aggressive features, such as tumour size, lymph-node-metastasis and tumour-nodus-metastases stage (p = 0.0146, p = 0.0037, p < 0.001, respectively).

Moreover, high levels of OLA1 predicted worse overall survival. Multivariate Cox regression analysis indicated that high expression of OLA1 was an independent prognostic factor for poor overall survival (p = 0.009). Additionally, OLA1 expression was positively correlated with Snail, and a combination of them revealed improved prognostic accuracy for GC patients. High expression of OLA1 predicts poor prognosis in GC patients and may be serviced as a novel target for GC.

OLA1, gastric cancer, prognosis, immunohistochemistry, Snail

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