eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
5/2021
vol. 38
 
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abstract:
Original paper

Concentration of proinflammatory cytokines in patients with ulcers as complications of type 2 diabetes mellitus

Daria Kupczyk
1
,
Rafał Bilski
1
,
Andrzej Przewięźlikowski
2
,
Renata Studzińska
3
,
Alina Woźniak
1

1.
Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
2.
Private Nursing Practice Andrzej Przewięźlikowski, Toruń, Poland
3.
Department of Organic Chemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
Adv Dermatol Allergol 2021; XXXVIII (5): 767-772
Online publish date: 2020/08/18
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Introduction
Difficult healing of chronic wounds is a serious problem for modern medicine. It leads to ulceration, especially in conditions such as diabetic foot syndrome or chronic venous insufficiency. This may be a result of chemical, physical, thermal or biological factors, among others. Analysis of mediators and molecular factors released by the abovementioned structure helps to better understand the mechanism of healing of chronic wounds and the formation of ulcers. The aim of this study was to assess excretion of selected cytokines in patients with ulcerations as a complication of diabetes mellitus type 2.

Material and methods
17 patients aged 68–87 took part in the assessment of wound healing in patients with ulceration in the course of diabetes mellitus type 2. The control group consisted of 21 healthy patients aged 32–62. In the blood serum bFGF, TNF-α, IL-4, TGF-β1, TGF-β2 and TGF-β3 were determined.

Results
A significant difference was found in bFGF, IL-4, TGF-β1, TGF-β2, and TGF-β3 levels. Concentration of bFGF was 12% lower in patients with ulcers than in the non-ulcerated control group (p = 0.013). IL-4 concentration was 46% lower in patients with ulcers than in the non-ulcerated control group (p = 0.002). TGF-β1, TGF-β2 and TGF-β3 concentrations were also lower in the group of patients with ulcers compared to those in the non-ulcerated control group.

Conclusions
Reduced concentrations of selected cytokines and growth factors may indicate abnormal activity of the cells that secrete them and affect the healing process of chronic wounds, hindering and delaying the healing process.

keywords:

type 2 diabetes, chronic venous insufficiency, ulcers, cytokines, growth factors

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