Dedifferentiation in adenoid cystic carcinoma
of the breast – an unexpected intraoperative finding
and a diagnostic challenge

Selcuk Cin; Ezgi Duman; Merve Cin

doi:10.5114/pjp.2025.158973

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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Case report

Dedifferentiation in adenoid cystic carcinoma of the breast – an unexpected intraoperative finding and a diagnostic challenge

Selcuk Cin

¹

,

Ezgi Duman

²

,

Merve Cin

³

Department of Pathology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
Department of Pathology, University of Health Sciences, Bagcılar Training and Research Hospital, Istanbul, Turkey
Department of Pathology, University of Health Sciences, Istanbul Training and Research Hospital, Istanbul, Turkey

Pol J Pathol 2025; 76 (4)

DOI: https://doi.org/10.5114/pjp.2025.158973

Online publish date: 2026/02/02

Article file

- Dedifferentiation in adenoid.pdf [5.50 MB]

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1. Lokuhetty D, White VA, Watanabe R, Cree IA, WHO classification of tumours, breast tumours. 5th ed. IARC, Lyon, France 2019, 142-145.

2. Cheuk W, Chan JK, Ngan RK. Dedifferentiation in adenoid cystic carcinoma of salivary gland: an uncommon complication associated with an accelerated clinical course. Am J Surg Pathol 1999; 23: 465-472.

3. Santiago AE, Teunissen N, Ricardo BFP, Cândido EB, Furtado RS, Silva Filho ALD. High-grade transformation in adenoid cystic carcinoma of the bartholin gland: case report. Rev Bras Ginecol Obstet 2021; 43: 980-984.

4. Righi A, Lenzi M, Morandi L, Flamminio F, De Biase D, Farnedi A, et al. Adenoid cystic carcinoma of the breast associated with invasive duct carcinoma: a case report. Int J Surg Pathol 2011; 19: 230-234.

5. Yang Y, Wang Y, He J, Pan G, Tuo X, Jiang A, et al. Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review. Diagn Pathol 2014; 9: 148.

6. Vasudevan G, John AM, Vijaykumar DK, Vallonthaiel AG. Adenoid cystic carcinoma of the breast with late recurrence and high-grade transformation. BMJ Case Rep 2023; 16: e252336.

Copyright: © 2026 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Dedifferentiation in adenoid cystic carcinoma of the breast – an unexpected intraoperative finding and a diagnostic challenge

Selcuk Cin 1 , Ezgi Duman 2 , Merve Cin 3

Selcuk Cin

¹

,

Ezgi Duman

²

,

Merve Cin

³