2/2026
vol. 35
Opis przypadku
Delayed encephalopathy after carbon monoxide poisoning in a 29-year-old female patient
- Private Health Care Institution RehStab in Limanowa, Poland
Adv Psychiatry Neurol 2026; 35 (2): 136-140
Data publikacji online: 2026/05/13
Plik artykułu
- Choi IS. Delayed neurologic sequelae in carbon monoxide intoxication. Arch Neurol 1983; 40: 433-435.
- Krishnamoorthy A, Shaikh IAA, Mitra S, Jasper A, Abhilashet KPP. Delayed neurological sequelae of carbon monoxide poisoning. Indian J Med Specialities 2015; 6: 63-66.
- Hsiao CL, Kuo HC, Huang CC. Delayed encephalopathy after carbon monoxide intoxication – long-term prognosis and correlation of clinical manifestations and neuroimages. Acta Neurol Taiwan 2004; 13: 64-70.
- Keim L, Koneru S, Ramos VF, Murr N, Hoffnung DS, Murman DL, et al. Hyperbaric oxygen for late sequelae of carbon monoxide poisoning enhances neurological recovery: case report. Undersea Hyperb Med 2018; 45: 83-87.
- Li C, Liang ML, Zhang XG. Research progress on the mechanisms of delayed encephalopathy in acute carbon monoxide poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022; 40: 543-546 [Article in Chinese].
- Wang Y, Zhou Z, Zhang D, Jiang Y. Predictors of delayed encephalopathy after acute carbon monoxide poisoning: a literature review. Front Med (Lausanne) 2025; 12: 1559264. DOI: 10.3389/fmed.2025.1559264.
- Suzuki Y. Risk factors for delayed encephalopathy following carbon monoxide poisoning: importance of the period of inability to walk in the acute stage. PLoS One 2021; 16: e0249395. DOI: 10.1371/journal.pone.0249395.
- Geraldo AF, Silva C, Neutel D, Neto LL, Albuquerque L. Delayed leukoencephalopathy after acute carbon monoxide intoxication. J Radiol Case Rep 2014; 8: 1-8.
- Kang EJ, Jeon SJ, Choi SC, Cho DH. Delayed encephalopathy after acute carbon monoxide poisoning: diffusion-weighted MR imaging findings. Clin Toxicol (Phila) 2012; 50: 273-277.
- Kim JH, Chang KH, Song IC, Kim KH, Kwon BJ, Kim HC. Delayed encephalopathy of acute carbon monoxide intoxication: diffusivity of cerebral white matter lesions. AJNR Am J Neuroradiol 2003; 24: 1592-1597.
- Weaver LK. Clinical practice. Carbon monoxide poisoning. N Engl J Med 2009; 360: 1217-1225.
- Park JH, Kim HJ, Kim JH, Kim MJ, Lee DH, Park JH, et al. Acute brain lesions on diffusion-weighted imaging and delayed neurologic sequelae in carbon monoxide poisoning. Diagnostics (Basel) 2020; 10: 698. DOI: 10.3390/diagnostics10090698.
- Huang CC, Ho CH, Chen YC, Lin HJ, Hsu CC, Wang JJ, et al. Gray-to-white matter ratio for prediction of delayed encephalopathy after acute carbon monoxide poisoning. Medicine (Baltimore) 2016; 95: e2939.
- Guo D, Hu H, Pan S. Oligodendrocyte dysfunction and regeneration failure: a novel hypothesis of delayed encephalopathy after carbon monoxide poisoning. Med Hypotheses 2020; 136: 109522. DOI: 10.1016/j.mehy.2019.109522.
- Lee Y, Cha YS, Kim SH, Kim H. Effect of hyperbaric oxygen therapy initiation time in acute carbon monoxide poisoning. Crit Care Med 2021; 49: e910-e919. DOI: 10.1097/CCM.0000000000005112.
- Hu H, Pan X, Wan H, Zhang Q, Wang Z. The effectiveness of hyperbaric oxygen therapy on delayed neurological sequelae after carbon monoxide poisoning: a systematic review and meta-analysis. Front Neurol 2021; 12: 653789.
- Liu J, Si Z, Liu J, Lin Y, Yuan J, Xu S, et al. Clinical and imaging prognosis in patients with delayed encephalopathy after acute carbon monoxide poisoning. Behav Neurol 2020; 2020: 1719360. DOI: 10.1155/2020/1719360.
- Oh S, Choi SC. Acute carbon monoxide poisoning and delayed neurological sequelae: a potential neuroprotection bundle therapy. Neural Regen Res 2015; 10: 36-38.
- Wang H, Li Y, Wu Q, Xu C, Liu Q. Combination of butylphthalide with umbilical mesenchymal stem cells for the treatment of delayed encephalopathy after carbon monoxide poisoning. Medicine (Baltimore) 2016; 95: e5412. DOI: 10.1097/MD.0000000000005412.
- Xu XM, Luo H, Rong B, Zheng XM, Wang F, Zhang SJ, Li ZX. Management of delayed encephalopathy after CO poisoning: an evidence-based narrative review. Medicine (Baltimore) 2019; 98: e18199. DOI: 10.1097/MD.0000000000018199.
- Song H, Yue A, Zhou X, Han W, Li Q. Evidence of clinical efficacy and pharmacological mechanism of N-butylphthalide in the treatment of delayed encephalopathy after acute carbon monoxide poisoning. Front Neurol 2023; 14: 1119871. DOI: 10.3389/fneur.2023.1119871.
- Xiang W, Xue H, Wang B, Li Y, Zhang J, Jiang C, et al. Combined application of dexamethasone and hyperbaric oxygen therapy yields better efficacy for patients with delayed encephalopathy after acute carbon monoxide poisoning. Drug Des Devel Ther 2017; 11: 513-519.
- Xiang W, Xue H, Wang B, Li Y, Zhang J, Jiang C, et al. Efficacy of N-butylphthalide and hyperbaric oxygen therapy on cognitive dysfunction in patients with delayed encephalopathy after acute carbon monoxide poisoning. Med Sci Monit 2017; 23: 1501-1506.
- Iwamoto K, Ikeda K, Mizumura S, Tachiki K, Yanagihashi M, Iwasaki Y. Combined treatment of methylprednisolone pulse and memantine hydrochloride prompts recovery from neurological dysfunction and cerebral hypoperfusion in carbon monoxide poisoning: a case report. J Stroke Cerebrovasc Dis 2014; 23: 592-595.
- Gill AL, Bell CN. Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM 2004; 97: 385-395.
- Thom SR, Taber RL, Mendiguren II, Clark JM, Hardy KR, Fisher AB. Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med 1995; 25: 474-480.
- Rudnicka-Czerwiec J, Bartosik-Psujek H. Glikokortykosteroidy i memantyna w leczeniu zespołu przewlekłych neurologicznych następstw po ciężkim zatruciu tlenkiem węgla – opis przypadku. Pol Przegl Neurol 2018; 14: 165-169.
- Lay-Son Rivas L, Trujillo-Godoy O, Alvarado-Pastenes M. Delayed-onset encephalopathy caused by carbon monoxide poisoning: resolution in a patient treated with citicoline. Neurologia 2015; 30: 453-455.
- Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, et al. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 2002; 347: 1057-1067.
- Buckley NA, Isbister GK, Stokes B, Juurlink DN. Hyperbaric oxygen for carbon monoxide poisoning: a systematic review and critical analysis of the evidence. Toxicol Rev 2005; 24: 75-92.
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