eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2022
vol. 39
 
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abstract:
Original paper

Dendritic cells may help differentiate discoid lupus erythematosus alopecia from lichen planopilaris

Agata D. Kłosowicz
1
,
Maciej Pastuszczak
1
,
Grzegorz Dyduch
2
,
Adriana Łukasik
1
,
Karolina Kozicka
1
,
Karolina Englert
1
,
Katarzyna Kaleta
1
,
Anna Wojas-Pelc
1

1.
Department of Dermatology, University Hospital, Krakow, Poland
2.
Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland
Adv Dermatol Allergol 2022; XXXIX (2): 298-303
Online publish date: 2022/05/09
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Introduction and aim
Primary cicatricial alopecia (PCA) encompasses a heterogeneous group of inflammatory diseases characterized by the replacement of hair follicle structures by fibrous tissue. Discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) are the most common causes of scarring alopecia. The distinction between both entities is often challenging because of significant clinical and histopathological overlap.
Aim: We hypothesized that dendritic cells which are implicated in PCA pathogenesis can provide a reliable histopathological clue to distinguish between these two entities.

Material and methods
In a retrospective cohort study including 51 patients diagnosed with LPP and DLE we mapped and quantified the distribution of dendritic cells. Cell count in lesional skin was performed on immunohistochemistry by using characteristic monoclonal antibodies to specific subpopulations of dendritic cells.

Results
We demonstrated that almost all subpopulations of dendritic cells were highly expressed in lesional skin of discoid lupus erythematosus patients in comparison with lichen planopilaris ones.

Conclusions
In the light of this observation, dendritic cells might be used as an additional clue in differential diagnosis of PCA.

keywords:

primary cicatricial alopecia, dendritic cells

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