eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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vol. 36
Original paper

Determinants of hgh-risk human papillomavirus infection in anogenital warts

Goknur Ozaydin-Yavuz, Serap Gunes Bilgili, Huseyin Guducuoglu, Ibrahim Halil Yavuz, Sema Elibuyuk-Aksac, Ayse Serap Karadag

Adv Dermatol Allergol 2019; XXXVI (1): 76-81
Online publish date: 2019/02/22
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Genital warts are benign epithelial tumours caused by human papilloma viruses (HPV), and are sexually transmitted. Genotyping of genital HPV bears great clinical significance in terms of treatment planning, follow-up, and prevention strategies.

To evaluate the distribution of high-risk HPV infection types in patients diagnosed with anogenital warts

Material and methods
A total of 66 patients with anogenital warts were enrolled. Punch biopsy samples were obtained from the lesions of each patient. After nucleic acid purification and DNA extraction, the presence of HPV DNA was ascertained using the PCR method, followed by HPV DNA genotyping. The relationship between HPV type distribution and age, gender, clinical location, and number of sexual partners was investigated.

Genotyping was performed and HPV genome was detected in 50 tissue samples (75.8%). Low-risk genotypes predominated with a prevalence of 62.1% (42/66). The most prevalent genotypes were HPV-6 (47%), and HPV-11 (13.6%). Other types detected included HPV-18 and HPV-3.

Genotyping of HPV provides significant clinical information regarding this family of viruses that play a role in the aetiology of a variety of genital cancers, as some of these malignancies are now considered preventable due to recent development of vaccines. We believe that our results may provide guidance on future vaccination programs in our country.


genital wart, human papilloma virus, anogenital wart

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