Polish Journal of Pathology
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ISSN: 1233-9687
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4/2025
vol. 76
 
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Case report

Diagnostic challenge of primary colonic poorly cohesive adenocarcinoma exhibiting gastric‑type immunohistochemistry profile and focal signet‑ring differentiation

Gizem Issın
1
,
Merve Tok
2
,
Diren Vuslat Çağatay
3
,
Oruç Numan Gökçe
3
,
Faruk Önder Aytekin
3

  1. Department of Pathology, Faculty of Medicine, Canakkale Onsekiz Mart University, Faculty Çanakkale, Turkey
  2. Department of General Surgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Çanakkale, Turkey
  3. Department of Pathology, Gumushane State Hospital, Gumushane, Turkey
Pol J Pathol 2025; 76 (4): 348-354
DOI: https://doi.org/10.5114/pjp.2025.159280
Online publish date: 2026/02/16
Article file
- Diagnostic challenge.pdf  [4.96 MB]
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9. Terada T. An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: I. Cytokeratin profile in 42 cases. Int J Clin Exp Pathol 2013; 6: 703-710.
10. Hrudka J, Matěj R, Nikov A, Tomyak I, Fišerová H, Jelínková K, et al. Loss of SATB2 expression correlates with cytokeratin 7 and PD-L1 tumor cell positivity and aggressiveness in colorectal cancer. Sci Rep 2022; 12: 19152.
11. Zhu X, Bledsoe JR. Frozen section diagnosis of gastrointestinal poorly cohesive and signet-ring cell adenocarcinoma: useful morphologic features to avoid misdiagnosis. Virchows Arch 2020; 477: 497-506.
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Copyright: © 2026 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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