eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
 
2/2022
vol. 60
 
Share:
Share:
more
 
 
abstract:
Original paper

Diagnostic performance of miR-21, miR-124, miR-132, and miR-200b serums in post-stroke cognitive impairment patients

Mei Yuan
1
,
Yi-Sha Guo
2
,
Xin-Xin Zhang
3
,
Zhen-Kun Gao
4
,
Xin-Ya Shen
4
,
Yu Han
2
,
Xia Bi
1

1.
Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, China
2.
Shanghai University of Sport, China
3.
Yandu Community Health Service Center, Jiangsu Province, China
4.
Shanghai University of Traditionary Chinese Medicine, China
Folia Neuropathol 2022; 60 (2): 228-236
Online publish date: 2022/06/30
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
The diagnosis of post-stroke cognitive impairment (PSCI) mainly depends on neuro-psychological evaluation. It still lacks a sensitive and objective diagnostic biomarker. MicroRNAs (miRNAs, miRs) are novel and potential disease biomarkers. Our aim was to detect which specific miRNA is a good diagnostic biomarker for PSCI.

Material and methods
There were 77 first-ever stroke patients enrolled. Blood samples were collected at 14 days after stroke. Level of serum miR-21, miR-124, miR-132, and miR-200b were determined by quantitative polymerase chain reaction. Mini-mental state examination (MMSE) scale was used to measure the cognitive function of patients. Factional anisotropy (FA) score of diffusion tensor imaging was applied to detect the alteration of white matter. In addition, the relationship between miRNA level and cognitive status was further explored by correlation analysis.

Results
Finally, 45 PSCI and 32 post-stroke cognitive normality (PSCN) patients were enrolled. The expression of miR-21, miR-132, and miR-200b in PSCI patients was higher than in PSCN patients. In particular, the miR-21 level was substantially correlated with MMSE scores (r = 0.752, p < 0.001) and FA value (r = 0.636, p < 0.001). Additionally, the diagnostic performance of miR-21 alone or the combination of miR-21 and FA values performed well.

Conclusions
The miR-21 alone or combination of miR-21 and FA values are valuable diagnostic biomarkers in discriminating PSCI from PSCN.

keywords:

stroke, cognition, microRNA, diagnosis, biomarkers

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.