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Folia Neuropathologica
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2/2020
vol. 58
 
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abstract:
Review paper

Does lipopolysaccharide-based neuroinflammation induce microglia polarization?

Daniel Hernandez Baltazar
1
,
Rasajna Nadella
2
,
Abril Alondra Barrientos Bonilla
3
,
Yazmin Montserrat Flores Martínez
4
,
Abraham Puga Olguín
5
,
Paola Heman Bozadas
6
,
María de Jesús Rovirosa Hernández
6
,
Iliana Tamara Cibrián Llanderal
6

1.
CONACyT-Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico
2.
IIIT Srikakulam, Rajiv Gandhi University of Knowledge Technologies (RGUKT), India
3.
Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico
4.
Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Ciudad de México, Mexico
5.
Instituto Interdisciplinario de Investigaciones de la Universidad de Xalapa, Xalapa, Veracruz, Mexico
6.
Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico
Folia Neuropathol 2020; 58 (2): 113-122
DOI: https://doi.org/10.5114/fn.2020.96755
Online publish date: 2020/06/30
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Lipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch between the survival and neuronal death in substantia nigra could be related to M1 (neurotoxic) and M2 (neuroprotective) microglia phenotypes. In this review, we present the current findings about microglia roles, biomarkers, and natural or synthetic immune modulators determined in the LPS-based murine model.
keywords:

cell signalling, lipopolysaccharide, proliferation, microglia cells, neuroinflammation
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