eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
6/2023
vol. 40
 
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abstract:
Original paper

Dupilumab for the treatment of moderate and severe atopic dermatitis: real-life experience

Jowita Sroka-Tomaszewska
1
,
Barbara Bulińska
1
,
Aleksandra Wilkowska
1
,
Roman J. Nowicki
1
,
Magdalena Trzeciak
1

  1. Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland
Adv Dermatol Allergol 2023; XL (6): 747-752
Online publish date: 2024/01/08
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Introduction:
Atopic dermatitis is a relapsing, chronic, inflammatory dermatosis. So far, treatment options for more severe forms of the disease have been limited. The prospect has changed with the advent of biological drug registrations. Dupilumab is a monoclonal antibody targeting the a subunit of the IL-4 receptor and is responsible for blocking the signalling of interleukin (IL) 4 (IL-4) and IL-13. Clinical trials conducted for over 10 years have confirmed the efficacy and safety of dupilumab’s treatment for atopic dermatitis.

Aim:
Evaluating the efficacy of dupilumab treatment in patients with moderate and severe atopic dermatitis in real life.

Material and methods:
We retrospectively evaluated medical records of patients treated with dupilumab for atopic dermatitis at the Department of Dermatology, Venereology and Allergology in Gdansk.

Results:
Ten patients in total were studied. They received dupilumab with standard dosing. The mean percentage reduction in SCORAD score was 52.16% in 8 weeks. Dupilumab was generally well tolerated and did not cause serious side effects. The most common adverse event was conjunctivitis.

Conclusions:
Dupilumab is an effective disease-modifying drug for patients with moderate to severe atopic dermatitis. The effects of treatment in real life are consistent with those demonstrated in clinical trials.

keywords:

atopic dermatitis, dupilumab, biological treatment

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