Family Medicine & Primary Care Review
eISSN: 2449-8580
ISSN: 1734-3402
Family Medicine & Primary Care Review
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3/2025
vol. 27
 
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Original paper

Effect of inspiratory muscle training on pulmonary functions, physical capacity, and quality of life: a randomized controlled trial in β-thalassemia children

Shaimaa Mohamed Mabrouk Bondok
1
,
Ahmed Bayuomy Abo Elatta
2
,
Hagar Ahmed El-Hadidy
3, 4
,
Amir Al Araby Abou Tahoun
4
,
Mahmoud Nabawy Mahmoud Khattab
1

  1. Department of Physical Therapy, Middle East University, Amman, Jordan
  2. Department of Basic Science, Horus University, New Damietta, Egypt
  3. Department of Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Benha University, Qalyubia, Egypt
  4. Department of Physical Therapy for Surgery and Burn, Faculty of Physical Therapy, Ahram Canadian University (ACU), Giza, Egypt
Family Medicine & Primary Care Review 2025; 27(3): 284-289
Online publish date: 2025/09/29
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1. Ayoub MD, Radi SA, Azab AM, et al. Quality of life among children with beta-thalassemia major treated in Western Saudi Arabia. Saudi Med J 2013; 34(12): 1281–1286.
2. Ismail AMA, Yasin FB, El-Hadidy HA, et al. Effect of pilates exercise on quality of life in patients with sickle cell disease. Electron J Gen Med 2025; 22(4): em654, doi: 10.29333/ejgm/16229.
3. Ismail AM. ChatGPT-assisted introduction of exercise advice to patients with phenylketonuria: restrictions and advantages. Health Prob Civil 2024, doi: 10.5114/hpc.2024.140504.
4. Abaas EE, Abdelazeim FH, Wahab MS, et al. Pulmonary Functions in Relation to Physical Fitness in Children with β-Thalassemia. Adv Rehabil 2024; 38(1): 1–8, doi: 10.5114/areh.2024.135841.
5. Sherief LM, Abd El-Salam SM, Kamal NM, et al. Nutritional biomarkers in children and adolescents with Beta-thalassemia-major: An Egyptian center experience. Biomed Res Int 2014; 2014: 261761, doi: 10.1155/2014/261761.
6. Hakeem GLA, Mousa SO, Moustafa AN, et al. Health-related quality of life in pediatric and adolescent patients with transfusion-dependent ß-thalassemia in upper Egypt (single center study). Health Qual Life Outcomes 2018; 16(1): 59, doi: 10.1186/s12955-018-0893-z.
7. Ismail DK, El-Tagui MH, Hussein ZA, et al. Evaluation of health-related quality of life and muscular strength in children with beta thalassemia major. Egypt J Med Hum Genet 2018; 19(4): 353–357, doi: 10.1016/j.ejmhg.2018.04.005.
8. Chan KC, Au CT, Leung AWK, et al. Pulmonary function in patients with transfusion-dependent thalassemia and its associations with iron overload. Sci Rep 2023; 13(1): 3674, doi: 10.1038/s41598-023-30784-9.
9. Abd El Hakeem AA, Mousa SMO, AbdelFattah MT, et al. Pulmonary functions in Egyptian children with transfusion-dependent β-thalassemia. Transfus Med 2019; 29(1): 55–60, doi: 10.1111/tme.12539.
10. Galvão F, Zanoni CT, Moreira MM, et al. Effects of home-based inspiratory muscle training on sickle cell disease (SCD) patients. Hematol Transfus Cell Ther 2021; 43(4): 443–452, doi: 10.1016/j.htct.2020.08.005.
11. Alahmari M, Elsisi HF, Ismail AMA. Functional outcomes of inspiratory muscle training in elderly with intensive care unit-acquired weakness and severe walking disability. Ir J Med Sci 2025; 194(2): 761–769, doi: 10.1007/s11845-025-03876-w.
12. Kaeotawee P, Udomittipong K, Nimmannit A, et al. A Effect of Threshold Inspiratory Muscle Training on Functional Fitness and Respiratory Muscle Strength Compared to Incentive Spirometry in Children and Adolescents with Obesity: A Randomized Controlled Trial. Front Pediatr 2022; 10: 942076, doi: 10.3389/fped.2022.942076.
13. Adam S, Afifi H, Thomas M, et al. Quality of Life Outcomes in a Pediatric Thalassemia Population in Egypt. Hemoglobin 2017; 41(1): 16–20, doi: 10.1080/03630269.2017.1312434.
14. Ismail AMA. Rehabilitation with virtual reality for leukemic children during the fourth COVID-19 Wave. Integr Cancer Ther 2021; 20: 15347354211049341, doi: 10.1177/15347354211049341.
15. Bostanci Ö, Mayda H, Yılmaz C, et al. Inspiratory muscle training improves pulmonary functions and respiratory muscle strength in healthy male smokers. Respir Physiol Neurobiol 2019; 264: 28–32, doi: 10.1016/j.resp.2019.04.001.
16. Ergezen G, Menek M, Demir R. Respiratory muscle strengths and its association with body composition and functional exercise capacity in non-obese young adults. Fam Med Prim Care Rev 2023; 25(2): 146–149, doi: 10.5114/fmpcr.2023.127671.
17. Ali Ismail A. Stress axis response to aerobic exercise in chronic obstructive pulmonary disease patients. Adv Rehabil 2022; 36(4): 24–32, doi: 10.5114/areh.2022.123180.
18. McConnell AK, Lomax M. The influence of inspiratory muscle work history and specific inspiratory muscle training upon human limb muscle fatigue. J Physiol 2006; 577(Pt 1): 445–457, doi: 10.1113/jphysiol.2006.117614.
19. Tran D, Munoz P, Lau EMT, et al. Inspiratory Muscle Training Improves Inspiratory Muscle Strength and Functional Exercise Capacity in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: A Pilot Randomised Controlled Study. Heart Lung Circ 2021; 30(3): 388–395, doi: 10.1016/j.hlc.2020.06.006.
20. Ismail AMA, El Gressy NSSA, Hegazy MD, et al. Effects of diaphragmatic breathing exercise on sleeping quality, cortisol, cardiovascular autonomic functions, depression, and fatigue: a randomized-controlled trial in women with systemic sclerosis. Reumatologia 2025; 63(2): 89–96, doi: 10.5114/reum/200193.
21. Chiappa GR, Roseguini BT, Vieira PJ, et al. Inspiratory muscle training improves blood flow to resting and exercising limbs in patients with chronic heart failure. J Am Coll Cardiol 2008; 51(17): 1663–1671, doi: 10.1016/j.jacc.2007.12.045.
22. Mills DE, Johnson MA, Barnett YA, et al. The effects of inspiratory muscle training in older adults. Med Sci Sports Exerc 2015; 47(4): 691–697.‏
23. Lima EV, Lima WL, Nobre A, et al. Inspiratory muscle training and respiratory exercises in children with asthma. J Bras Pneumol 2008; 34(8): 552–558, doi: 10.1590/s1806-37132008000800003.
24. Elnaggar RK. A randomized placebo-controlled study investigating the efficacy of inspiratory muscle training in the treatment of children with bronchial asthma. J Asthma 2021; 58(12): 1661–1669, doi: 10.1080/02770903.2020.1821058.
25. Jones HN, Crisp KD, Moss T, et al. Effects of respiratory muscle training (RMT) in children with infantile-onset Pompe disease and respiratory muscle weakness. J Pediatr Rehabil Med 2014; 7(3): 255–265, doi: 10.3233/PRM-140294.
26. Elshafey MA, Alsakhawi RS. Inspiratory Muscle Training and Physical Fitness in Children with Down Syndrome: A Randomized Controlled Trial. Arch Phys Med Rehabil 2022; 103(12): 2279–2287, doi: 10.1016/j.apmr.2022.04.005.
27. Moawd SA, Azab AR, Ibrahim ZM, et al. Impacts of Respiratory Muscle Training on Respiratory Functions, Maximal Exercise Capacity, Functional Performance, and Quality of Life in School-Aged Children with Postoperative Congenital Diaphragmatic Hernia. Dis Markers 2020; 2020: 8829373, doi: 10.1155/2020/8829373.
28. Keles MN, Elbasan B, Apaydin U, et al. Effects of inspiratory muscle training in children with cerebral palsy: a randomized controlled trial. Braz J Phys Ther 2018; 22(6): 493–501, doi: 10.1016/j.bjpt.2018.03.010.
29. Sarac DC, Bayraktar D, Ozer Kaya D, et al. The effects of inspiratory muscle training on cardiorespiratory functions in juvenile idiopathic arthritis: A randomized controlled trial. Pediatr Pulmonol 2024; 59(3): 562–573, doi: 10.1002/ppul.26783.
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