eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
4/2019
vol. 36
 
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abstract:
Letter to the Editor

Effect of polyvalent bacterial lysate on the clinical course of pollen allergic rhinitis in children

Kamil P. Janeczek
,
Andrzej Emeryk
,
Piotr Rapiejko

Adv Dermatol Allergol 2019; XXXVI (4): 504-505
Online publish date: 2019/08/30
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Seasonal allergic rhinitis (SAR) is caused by various allergens, including wind-pollinated plants, and mainly by grass pollen allergens in Poland. The disease reduces the quality of life of patients and requires intensive treatment in the pollen season [1].
Polyvalent bacterial lysates (PBL) have been used for many years to prevent respiratory tract infections in children and adults [2]. Recent research also draws attention to the immunoregulatory potential of PBL, indicating the possibility of their future use in the prevention and treatment of atopic dermatitis, AR and asthma [3–7].
The aim of the study was to assess the impact of PBL on the clinical course of childhood SAR.
The study included 38 children aged 5–17 years (27 males; mean age: 9 ±3.2 years) with SAR caused by grass pollen, randomly selected from the group of children treated at the Outpatient Clinic of the University Children’s Hospital in Lublin. Main inclusion criteria were: SAR symptoms for at least two last grass pollen seasons, positive skin prick test results with grass pollen allergens and/or serum allergen specific immunoglobulin E (IgE) level > 0.70 IU/ml. The main exclusion criteria were: allergen immunotherapy over the last 3 years, presence of other chronic diseases of the nose and/or paranasal sinuses.
All children underwent standard SAR treatment from the beginning of the grass pollen season (oral antihistamines or/and intranasal corticosteroids “on demand”). Patients were randomly assigned to two groups. One group (n = 20) received mechanical PBL (PMBL-Ismigen®, Lallemand Pharma AG, Switzerland) (group P) during the grass pollen season, sublingually for 10 consecutive days per month for 3 consecutive months (May, June and July 2017). The pollen season in Lublin started on 19 May 2017 and ended on 12 August 2017. The remaining patients (control group – group C, n = 18) did not receive PMBL. Throughout the study, the children’s parents filled in the patient’s diary every day, when the symptoms of SAR were noticed. The study included two 5-week periods during which patients had 3 visits (V): V1 – screening/randomization visit (19.05–30.05.2017), V2 (23.06–5.07.2017) and V3 (1.08–12.08.2017).
The severity of SAR symptoms and associated eye symptoms were assessed by the Total Nasal Symptom Score (TNSS) and Total Ocular Symptom Score (TOSS). Nasal Peak Inspiratory Flow (PNIF) values were measured by Youlten Peak Flow Meter...


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