Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity

Simona Stolnicu; Cristian Podoleanu; Ildiko Orban; Rozsnyai Francisc

doi:10.5114/pjp.2021.106446

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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1/2021
vol. 72

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abstract:

Letter to the Editor

Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity

Simona Stolnicu

¹

,

Cristian Podoleanu

²

,

Ildiko Orban

³

,

Rozsnyai Francisc

⁴

Department of Pathology, University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania

Department of Cardiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania

Department of Pathology, Emergency Hospital, Targu Mures, Romania

Department of Gynecology and Obstetrics, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania

Pol J Pathol 2021; 72 (1): 84-86

DOI: https://doi.org/10.5114/pjp.2021.106446

Online publish date: 2021/05/31

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Gastrointestinal type of endometrial carcinoma is a newly described entity for which clearly defined diagnostic criteria have only recently been published. Among morphologic criteria, gastrointestinal mucinous adenocarcinoma of endometrium must not show a typical endometrioid component. We present a case with morphologic diversity, with areas showing gastric and intestinal differentiation as well as an endometrioid-like component. However, the endometrioid-like component not only did not show classic squamous metaplasia, but was also MUC6-positive, while the positivity for ER/PR was only focal. The recognition of gastric/gastrointestinal differentiation in endometrial carcinomas is best accomplished using both morphology and immunohistochemistry rather than either alone.

keywords:

Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity

Simona Stolnicu 1 , Cristian Podoleanu 2 , Ildiko Orban 3 , Rozsnyai Francisc 4

endometrial carcinoma, gastrointestinal differentiation, morphology

Simona Stolnicu

¹

,

Cristian Podoleanu

²

,

Ildiko Orban

³

,

Rozsnyai Francisc

⁴