eISSN: 1731-2531
ISSN: 1642-5758
Anaesthesiology Intensive Therapy
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank


 
1/2019
vol. 51
 
Share:
Share:
more
 
 
abstract:
Original article

Epileptiform EEG patterns during different techniques of induction of general anaesthesia with sevoflurane and propofol: a randomised trial

Michał J. Stasiowski
1
,
Radosław Marciniak
1
,
Anna Duława
2
,
Lech Krawczyk
1
,
Przemysław Jałowiecki
1

1.
Department of Anaesthesiology and Intensive Therapy, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
2.
Department of Anaesthesiology and Intensive Care, Medical University of Silesia, SMK in Katowice, Poland
Anestezjologia Intensywna Terapia 2019, tom 51, nr 1, 21–34
Online publish date: 2019/09/12
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Background
The aim of the study was to assess the influence of volatile induction of general anaesthesia with sevoflurane using two different techniques and intravenous anaesthesia with propofol on the possible presence of epileptiform electroencephalograph patterns during the induction of general anaesthesia.

Methods
Sixty patients (age 18–70 years) were recruited. Exclusion criteria included a history of epilepsy, neurological or neurosurgical diseases, pre-existing EPs (epileptiform patterns) in initial EEG recordings, medication interfering with EEG patterns. Patients were randomly allocated into three different groups, namely: A (sevoflurane, increasing concentrations technique); B (sevoflurane, vital capacity technique); and C (intravenous propofol). The clinical and instrumental monitoring included arterial blood pressure, heart rate, standard electrocardiography II, arterial oxygen saturation, facial electromyography, fraction of inspired sevoflurane, fraction of expired sevoflurane, minimum alveolar concentration of sevoflurane, and BIS.

Results
Neurophysiological analysis of EEGs showed different EPs: polyspikes (PS), rhythmic polyspikes (PSR), and periodic epileptiform discharges (PED). EPs (P < 0.05) were observed in group A (56%) and group B (37%), but not in group C. One patient in group B presented clinical seizures. No significant differences in the vital parameters and anaesthesia parameters between groups was observed, regardless of the presence of EPs, which were associated with both low and more likely high (falsely indicating awakening from anaesthesia) BIS scores.

Conclusion
Our study shows that the BIS score variations do not identify epileptiform activity, which was associated with both low and high scores. In addition, the sevoflurane concentration reached either sedative or toxic concentrations

keywords:

anaesthetics, volatile, sevoflurane; anaesthetics, intravenous, propofol; anaesthesia, monitoring, bispectral index; electroencephalogram, epileptiform patterns

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe