eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
4/2019
vol. 36
 
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abstract:
Original paper

Evaluation of plasma levels of tissue factor and tissue factor pathway inhibitor in patients with psoriasis

Anna Domagała
,
Elżbieta Wojtowicz-Prus
,
Joanna Dubis
,
Wojciech Witkiewicz
,
Anna Czarnecka

Adv Dermatol Allergol 2019; XXXVI (4): 442-448
Online publish date: 2019/08/30
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Introduction
Psoriasis is a chronic, recurrent, inflammatory skin disorder with systemic involvement. It has recently been established that psoriasis is associated with an increased cardiovascular risk. Chronic skin-specific inflammation may promote atherosclerosis. Myocardial infarction or stroke can also be a result of underlying haemostasis disorders. Disorders in fibrinolysis and thrombosis in patients with psoriasis have been observed by many authors.

Aim
This study points to the key role played by the tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the extrinsic pathway of blood coagulation and the potential influence of microvascular disorders in inflamed psoriatic skin on TF and TFPI activity.

Material and methods
The study included 47 patients with active psoriasis vulgaris, hospitalized in the Dermatological Ward of the Regional Specialist Hospital, Research and Development Centre in Wroclaw, as well as 18 people from the control group.

Results
There were significant differences in the blood concentrations of TF and TFPI in patients with psoriasis when compared to the control group. A low TFPI concentration in psoriatic patients may indicate an increased risk of atherosclerosis. Interpretation of a decreased level of TF in patients with psoriasis is difficult because it seems to be at odds with observations among patients with other atherosclerosis risk factors such as hypertension, hyperlipidaemia, diabetes or smoking.

Conclusions
It appears that further studies are necessary to explain this problem, perhaps to include an evaluation of TF levels in psoriatic skin.

keywords:

psoriasis vulgaris, haemostasis, coagulation, cardiovascular diseases

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