eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2008
vol. 33
 
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abstract:

Experimental immunology
Anti-inflammatory effects of riboflavin and morphine on zymosan-induced peritonitis in Swiss mice

Agnieszka I. Mazur
,
Joanna Natorska
,
Ewa Wypasek
,
Elżbieta Kołaczkowska
,
Barbara Płytycz

(Centr Eur J Immunol 2008; 33 (3): 98-101)
Online publish date: 2008/05/05
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We have previously shown that in several strains of mice morphine abolishes inflammation-related pain symptoms already at 5 mg/kg, but inhibits inflammation only at 20 mg/kg. Other investigators have shown that also riboflavin (vitamin B2) has antinociceptive and anti-inflammatory activities. In particular, highly purified riboflavin is a promising therapeutic agent for both bacterial infections and toxin-induced septic shock, mainly due to inhibition of pro-inflammatory cytokines/chemokines and nitric oxide production. The aim of present study was to examine anti-inflammatory effects of morphine, riboflavin and combined action of the both agents injected intraperitoneally (i.p.) 30 min before zymosan treatment in Swiss mice. Animals pre-injected with PBS formed the control group. At 4th hour after PBS-Zymosan injection, the number of peritoneal PMNs reached 20 × 106. The number of PMNs was similar in animals pre-injected with low dose of morphine (5 mg/kg b.w.) or riboflavin (20 and 50 mg/kg b.w.) while intraperitoneal influx of PMNs was significantly inhibited in animals pre-injected with high dose of morphine (20 mg/kg b.w.) or riboflavin (100 mg/kg b.w.). Similar anti-inflammatory effect was achieved by pre-injection with the combined low dose of morphine (5 mg/kg b.w.) with riboflavin (50 mg/kg b.w.).
keywords:

peritonitis, inflammation, morphine, riboflavin, zymosan, cytokine, Swiss mice

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