eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1-2/2005
vol. 30
 
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abstract:

Experimental immunology
Azathioprine-induced severe aplastic anaemia in thiopurine S-methyltransferase deficient patient with Crohn’s disease

Barbara Zdziarska
,
Mateusz Kurzawski
,
Ewa Wierzbicka-Paczos
,
Anna Kozłowska
,
Maria Chosia
,
Andrzej Pawlik
,
Marek Drozdzik

Centr Eur J Immunol 2005; 30 (1-2): 1-3
Online publish date: 2006/07/26
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TPMT is an enzyme that catalyses S-methylation of thiopurine drugs, which activity is genetically determined. TPMT-deficient patients are at risk of toxicity after standard doses of thiopurine drugs. We describe a case of Crohn’s disease diagnosed patient inheriting genetic TPMT deficiency (TPMT*3A/*3A genotype), who developed severe aplastic anaemia, confirmed by biopsy, after 55 days of treatment with AZA at a standard daily dose of 2.5 mg/kg. This case demonstrates the importance of TPMT polymorphism testing in order to prevent myelotoxicity during treatment with thiopurine drugs.
keywords:

Thiopurine S-methyltransferase, azathioprine, Crohn’s disease, aplastic anaemia

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