eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2009
vol. 34
 
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abstract:

Experimental immunology
Effects of enoxaparin and onion extract on cytokine production in skin fibroblasts

Michał Pikuła
,
Maria E. Żebrowska
,
Piotr Trzonkowski
,
Andrzej Myśliwski
,
Małgorzata Sznitowska

Centr Eur J Immunol 2009; 34 (2): 68-71
Online publish date: 2009/05/20
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Hypertrophic scars and keloids are fibroproliferative disorders of the skin which present serious problems in esthetic dermatology and dermatosurgery. It is believed that an increased secretion of cytokines and growth factors including IL-6, VEGF and TNF-α plays a pivotal role in the pathogenesis of hypertrophic scars and keloids. Prevention and treatment of problematic scars includes topical preparations with heparin and onion extract. Nevertheless, the effectiveness of these agents is still controversial. Here we show that enoxaparin and onion extract reduced the level of both IL-6 and VEGF in the culture of fibroblasts. This effect was the strongest in 20 µg/ml of enoxaparin and 50 µg/ml of onion extract. Our results may add to the explanation of beneficial effects of enoxaparin and onion extract on keloid scars in vivo.
keywords:

LMW heparin, enoxaparin, onion, keloids, cytokines

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