eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank

2/2008
vol. 33
 
Share:
Share:
more
 
 
abstract:

Experimental immunology
Effects of morphine on murine peritonitis – interstrain differences

Joanna Natorska
,
Barbara Płytycz

(Centr Eur J Immunol 2008; 33 (2): 33-36)
Online publish date: 2008/05/05
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
We have shown previously that supplementation of inflammation-inducing factor with a high dose of morphine inhibits intraperitoneal accumulation of exudatory cells in representatives of fish but not in amphibian species, and in some but not all strains of mice. In a case of mice, males were ip injected with zymosan (40 mg/kg, Z group) or with zymosan supplemented with morphine (20 mg/kg, ZM groups). At 4th hour of peritonitis, the total numbers of intraperitoneal leukocytes (PTLs), and numbers of polymorphonuclear leukocytes (PMNs) were significantly lower in ZM animals than in their Z counterparts in Swiss, C57C3H, Balb/c, and C57BL/6 strains but not in CBA mice. The aim of the present investigations was to monitor the time course of peritonitis (up to 24 hours) in Z and ZM groups of males of four strains. The results fully confirmed the lack of anti-inflammatory action of morphine in CBA strain. In Balb/c, C57BL/6, and Swiss mice, the number of intraperitoneal PMNs was lower in ZM groups during the whole investigated period, being statistically different during the first 12 or 8 hours. In a sharp contrast, the time course of intraperitoneal PMNs accumulation was very similar in Z and ZM groups of CBA mice.
keywords:

zymosan, peritonitis, time course, morphine, mice

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe