eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2009
vol. 34
 
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abstract:

Experimental immunology
In vitro modulatory effects of ciprofloxacin and chloramphenicol on the rabbit phagocytic cells

Anna Sierosławska
,
Anna Rymuszka
,
Andrzej K. Siwicki

Centr Eur J Immunol 2009; 34 (2): 77-80
Online publish date: 2009/05/20
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Ciprofloxacin and chloramphenicol belong to the antimicrobials used in veterinary medicine for, among others, rabbit otitis, respiratory or skin diseases treatment.
In the study ciprofloxacin (Polfa, Grodzisk) and water soluble chloramphenicol (Sigma) at clinically relevant concentrations were tested on their impact on inducible nitric oxide synthase activity, tumor necrosis factor-a production and the intracellular level of cAMP in the phagocytic cells isolated from rabbit blood. Both antibiotics exhibited some modulatory effects on the studied parameters.
keywords:

ciprofloxacin, chloramphenicol, rabbit phagocytic cells, tumor necrosis factor-a, cyclic AMP, inducible nitric oxygen synthase

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