eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank

3/2003
vol. 28
 
Share:
Share:
more
 
 
abstract:

Experimental immunology

The analysis of L-selectin expression intensity (CD62L) on B-lymphocytes in B-cell chronic lymphocytic leukemia cells (B-CLL)

Grażyna Pałynyczko
,
Joanna Kopeć-Szlęzak
,
Lech Konopka
,
Urszula Podstawka

Centr Eur J Immunol 2003; 28 (3): 105–109
Online publish date: 2004/05/04
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Decreased percentage of B cells expressing L-selectin in B-cell chronic lymphocytic leukemia (B-CLL) is known from literature. The purpose of our studies was to compare the intensity of L-selectin expression on subpopulation of L-selectin positive B-lymphocytes in untreated and treated patients with B-CLL.
The lymphocytes were obtained from peripheral blood of 70 patients suffering from B-CLL (40 untreated and 30 after the treatment) and 20 healthy blood donors. The percentage of positive cells and intensity of CD62 L-selectin expression (RFI) were measured on CD19+ B lymphocytes using tri-color fluorochrom labeled monoclonal antibodies and flow cytometric analysis.
The lower percentage of L-selectin positive B-cells paralleled with considerable decrease of this selectin intensity was observed in patients with B-CLL in comparison to healthy subjects. Both these changes may contribute to the impaired adhesion and migration of B-cells in B-CLL resulting in the accumulation of these cells in the peripheral blood. In a group of patients entirely responding to the treatment the tendency toward normalization of both measured parameters has been observed.
keywords:

L-selectin, B-cells, B-CLL

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe