eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2009
vol. 34
 
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abstract:

Experimental immunology
The influence of iron on cell-mediated and humoral-mediated immunity in mice

Sylwia Terpiłowska
,
Andrzej K. Siwicki

Centr Eur J Immunol 2009; 34 (2): 57-60
Online publish date: 2009/05/20
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The aim of this study was to examine the effect of iron on IL-1a and IL-6 production. Moreover, the proliferative response of lymphocytes, the metabolic activity of phagocyting cells, the lysozyme activity and g-globulins level were examined in mice peripheral blood.

The experiments were performed on NRMI mice, which were intraperitoneally injected with 0.5 ml: NaCl (control), 150 mg Fe, or 300 mg Fe per body weight, in the form of iron chloride solution.

The results showed that iron decreased statistically significantly IL-1a concentration in mouse serum after injection of both iron doses. No differences between control and experimental groups were observed in other studied parameters.
keywords:

iron, cellular immunity, humoral immunity, mice

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