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ISSN: 1233-9687
Polish Journal of Pathology
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4/2015
vol. 66
 
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abstract:
Original paper

Expression of β-catenin and its correlation with metastatic progression of esophagogastric junction adenocarcinoma

Janusz Wlodarczyk
,
Lucyna Rudnicka-Sosin
,
Jarosław Kużdżał

Pol J Pathol 2015; 66 (4): 414-419
DOI: https://doi.org/10.5114/pjp.2015.57256
Online publish date: 2016/02/05
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The evaluation of β-catenin expression in adenocarcinoma of the esophagogastric junction and its influence on cancer progression.

Sixty-one patients who were diagnosed with adenocarcinoma of the esophagogastric junction were examined. We evaluated β-catenin distribution in the cell membrane and the cell nucleus in adenocarcinoma of the esophagogastric junction type 1 and type 3.

Our findings showed lack of a statistically significant difference in evaluation of adenocarcinoma type 1 and type 3 aggressiveness. However, we found a statistically significant association with the T and N stage, although we did not find an effect of them on patient survival.

Patients with cellular membrane and cell nucleus staining comprise a group of patients with higher risk of malignancy progression in adenocarcinoma of the esophagogastric junction types 1 and 3.
keywords:

β-catenin, esophago-gastric junction, adenocarcinoma
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