FECAL MICROBIOTA TRANSPLANTATION: A REVOLUTIONARY THERAPY FOR METABOLIC DISORDERS

Wiktoria Sielwanowska; Maciej Dubaj; Karol Bigosiński; Aleksandra Dembowska; Domnik Porada

doi:10.5114/hpc.2025.150238

eISSN: 2354-0265
ISSN: 2353-6942

Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO

Current issue Archive Online first About the journal Editorial board Reviewers Abstracting and indexing Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

Send email

Copy url:

abstract:

Review paper

FECAL MICROBIOTA TRANSPLANTATION: A REVOLUTIONARY THERAPY FOR METABOLIC DISORDERS

Wiktoria Sielwanowska

¹

,

Maciej Dubaj

¹

,

Karol Bigosiński

¹

,

Aleksandra Dembowska

¹

,

Domnik Porada

²

Section of Diabetology at the Student Scientific Circle at the Department and Clinic of Endocrinology, Diabetology, and Metabolic Diseases, Medical University of Lublin, Poland
Department and Clinic of Endocrinology, Diabetology, and Metabolic Diseases, Medical University of Lublin, Poland

Health Problems of Civilization

DOI: https://doi.org/10.5114/hpc.2025.150238

Online publish date: 2025/05/19

View full text Get citation

PlumX metrics:

Recent interest in the role of gut microbiota in metabolism has led to exploration of fecal microbiota transplantation (FMT) as a therapy for metabolic disorders, including obesity. However, its effectiveness remains unclear. This review analyzed studies published between 2019 and 2025 from PubMed and Google Scholar using the keywords "obesity" and "FMT". Findings indicate that FMT can reduce insulin resistance, as evidenced by decreased HOMA-IR levels. In several trials, improved glucose tolerance and lipid profiles were also observed, suggesting broader metabolic benefits. Donor selection and recipient compatibility emerged as important factors influencing outcomes, highlighting the need for standardized protocols. Most studies reported significant gut microbiota shifts post-FMT, including increased Bacteroides/Firmicutes ratios and higher Bifidobacterium and Lactobacillus abundance. Only one study found no significant metabolic improvements. FMT appears promising for metabolic disorder treatment, particularly alongside diet, lifestyle changes, or bariatric surgery. Given these findings, FMT may serve as a valuable adjunct in obesity management, though not a standalone cure. Further large-scale studies are needed to confirm its therapeutic potential.

keywords:

FECAL MICROBIOTA TRANSPLANTATION: A REVOLUTIONARY THERAPY FOR METABOLIC DISORDERS

Wiktoria Sielwanowska 1 , Maciej Dubaj 1 , Karol Bigosiński 1 , Aleksandra Dembowska 1 , Domnik Porada 2

HOMA-IR index, FMT, BMI, metabolic disorders, obesity

Wiktoria Sielwanowska

¹

,

Maciej Dubaj

¹

,

Karol Bigosiński

¹

,

Aleksandra Dembowska

¹

,

Domnik Porada

²