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ISSN: 1233-9687
Polish Journal of Pathology
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vol. 69
Case report

Fibroma of the breast: a rare tumour in the spectrum of the benign spindle cell tumours of the mammary stroma

Magro Gaetano, Angelico Giuseppe, Spadola Saveria, Ragusa Rosalia, Righi Alberto, Orvieto Enrico

Pol J Pathol 2018; 69 (2): 189-194
Online publish date: 2018/07/06
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Benign spindle cell tumours of the mammary stroma comprises different lesions that show a variable degree of fibroblastic/myofibroblastic differentiation. We herein report a previously under-recognised hypocellular fibrocollagenous tumour of the breast, for which the term “fibroma” is proposed. The tumour was composed of CD34-positive bland-looking spindle cells embedded in an abundant hyalinised stroma. Fluorescence in situ hybridisation (FISH) showed 13q14 deletion in most neoplastic cells, a chromosomal alteration typically found in mammary myofibroblastoma. Based on morphological, immunohistochemical, and cytogenetic features, we suggest that fibroma belongs to the group of the benign spindle cell tumours of the mammary stroma.

breast, mammary stroma, fibroma, benign spindle cell tumour, 13q14 deletion

Magro G. Differential Diagnosis of Benign Spindle Cell Lesions. Surg Pathol Clin 2018; 11: 91-121.
Magro G, Michal M, Bisceglia M. Benign spindle cell tumors of the mammary stroma: diagnostic criteria, classification, and histogenesis. Pathol Res Pract 2001; 197: 453-466.
Magro G, Bisceglia M, Michal M, et al. Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinicopathological analysis of 13 cases in favor of a unifying histologic concept. Virchows Arch 2002; 440: 249-260.
Magro M, Fletcher CDM, Eusebi. Myofibroblastoma. In: WHO classification of tumours of the breast. Lakhani S, Ellis IO, Schnitt SJ, et al. (eds). 4th ed. IARC press, Lyon 2012; 130-131.
Magro G. Mammary myofibroblastoma: an update with emphasis on the most diagnostically challenging variants. Histol Histopathol 2016; 31: 1-23.
Toker C, Tang CK, Whitely JF, et al. Benign spindle cell breast tumor. Cancer 1981;48: 1615-1622.
Böger A.. Benign spindle cell tumor of the male breast. Path Res Pract 1984; 178: 395 398.
Magro G, Bisceglia M, Pasquinelli G. Benign spindle cell tumor of the breast with prominent adipocytic component. Ann Diagn Pathol 1998; 2: 306-311.
Chan KW, Ghadially FN, Alagaratnam. Benign spindle cell tumour of breast-a variant of spindle cell lipoma or fibroma of breast? Pathology 1984;16: 331-337.
Smith DN, Denison CM, Lester SC. Spindle cell lipoma of the breast. A case report. Acta Radiol 1996; 37: 893-895.
Mulvany NJ, Silvester AC, Collins JP. Spindle cell lipoma of the breast. Pathology 1999; 31: 288-291.
Bégin LR. Myogenic stromal tumor of the male breast (socalled myofibroblastoma). Ultrastruct Pathol 1991; 15: 613-622.
Damiani S, Miettinen M, Peterse JL, et al, Solitary fibrous tumor (myofibroblastoma) of the breast. Virchows Arch 1994; 425: 89-92.
Meguerditchian AN, Malik DA, Hicks DG, et.al. Solitary fibrous tumor of the breast and mammary myofibroblastoma: the same lesion? Breast J 2008; 14: 287-292.
Magro G, Sidoni A, Bisceglia M. Solitary fibrous tumour of the breast: distinction from myofibroblastoma. Histopathology 2000; 3: 189-190.
Robinson DR, Wu YM, Kalyana-Sundaram S, et al. Identification of recurrent NAB2–STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet 2013; 5: 180-185.
Doyle LA, Vivero M, Fletcher CD, et al. Nuclear expression o1f STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mol Pathol 2014; 27: 390-395.
Yoshida A, Tsuta K, Ohno M, et al. STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors. Am J Surg Pathol 2014; 38: 552-559.
Magro G, Angelico G, Leone G, et al. Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining. Pathol Res Pract 2016; 212: 463-467.
Halpert B, Dial DL. Fibroma of the Breast. Am J Pathol 1933; 9: 905-907.
Rosen PP. Rosen’s Breast Pathology. Lippincott Williams & Wilkins, Philadelphia 2009.
Devouassoux-Shisheboran M, Schammel MD, Man YG, et al. Fibromatosis of the breast: age-correlated morphofunctional features of 33 cases. Arch Pathol Lab Med 2000; 124: 276-280.
Magro G, Gurrera A, Scavo N, et al. Fibromatosis of the breast: a clinical, radiological and pathological study of 6 cases. Pathologica 2002; 94: 238-246.
Falconieri G, Lamovec J, Mirra M, et al. Solitary fibrous tumor of the mammary gland: a potential pitfall in breast pathology. Ann Diagn Pathol 2004; 8: 121-125.
Fritchie KJ, Carver P, Sun Y, et al. Solitary fibrous tumor: is there a molecular relationship with cellular angiofibroma, spindle cell lipoma, and mammary-type myofibroblastoma? Am J Clin Pathol 2012; 137: 963-970.
Magro G. Mammary myofibroblastoma: a tumor with a wide morphologic spectrum. Arch Pathol Lab Med 2008; 132: 1813-1820.
Magro G, Righi A, Casorzo L, et al. Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region. Hum Pathol 2012; 43:1887-1893.
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