eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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SCImago Journal & Country Rank
1/2021
vol. 59
 
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abstract:
Case report

Globular glial tauopathy, a newly recognized white matter tauopathy, with depression/anxiety disorder: report and review of classification

Maher Kurdi
1
,
Badrah Saeed Alghamdi
2, 3
,
Jeremy Parfitt
4
,
Lee Cyn Ang
4

1.
Department of Pathology, Faculty of Medicine, Rabigh, King Abdulaziz University, Saudi Arabia
2.
Department of Physiology, Neuroscience Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
3.
Pre-Clinical Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
4.
Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Canada
Folia Neuropathol 2021; 59 (1): 98-103
Online publish date: 2021/03/12
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Several studies have recently described 4-repeat tauopathies that are characterized by the presence of globular glial inclusions. These inclusions are astrocytic or oligodendroglial, show extensive white matter involvement, and have a wide range of neuropathological and clinical presentations. Globular glial tauopathy (GGT) is classified into three subtypes according to clinical manifestations. Type I is characterized by frontotemporal lobar degeneration and represents a group of diseases with diverse clinical and histopathological features. Some of these disorders are associated with abnormal microtubule-associated protein tau gene. Type II presents as motor impairment due to pyramidal involvement, whereas type III is a combination of the features of types I and II. This report describes a rare case of GGT that manifested as depression and anxiety and demonstrates its neuropathological features. We have also compared the features of this case with those of previously reported cases and have revisited the classification.
keywords:

frontotemporal lobe degeneration, tauopathies, 4-repeat tauopathies, white matter tauopathy, globular glial tauopathy

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