eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
vol. 35
Letter to the Editor

Hand dermatitis with Hanseniaspora uvarum as a plausible causative agent

Marek Jankowski, Tomasz Jagielski, Grażyna Misiak, Rafał Czajkowski

Adv Dermatol Allergol 2018; XXXV (6): 641-643
Online publish date: 2018/08/13
View full text
Get citation
JabRef, Mendeley
Papers, Reference Manager, RefWorks, Zotero
The ascomycetes genus Hanseniaspora was created with the description of Hanseniaspora valbyensis in 1912. Yet, the first species from this genus was described as early as in 1870 under the name of Saccharomyces apiculatus [1]. Over the years, a total of six species of Hanseniaspora yeasts have been described. Molecular taxonomy studies have demonstrated Hanseniaspora as the teleomorphic genus of Kloeckera species. Hanseniaspora uvarum is a synonym and valid name of the aforesaid species S. apiculatus, whereas its anamorph is known as Kloeckera apiculata [2].
Hanseniaspora uvarum is commonly found on fresh fruit, and grapes in particular, being an important part of the natural microbiome involved in alcoholic fermentation. The fungus has also been isolated from soil, plants, fruit-eating insects, birds and seafood [3]. The occurrence of H. uvarum in humans is very unusual with only seven documented isolations in the literature [4–7].
Here we present a patient in whom H. uvarum was isolated from the skin lesion, which resolved after antifungal therapy. To the best of our knowledge, this is the first case where H. uvarum could be linked to the human pathology.
A 51-year-old, otherwise healthy and immunocompetent Polish woman presented to the dermatologist with a 3-month history of pruritic lesions localized on the dorsal and lateral aspects of the distal interphalangeal joints of the middle and ring finger of her left hand (Figure 1 A). The lesions, consisting of small vesicles and occasionally pustules on a relatively well-demarcated erythematous base with lichenification, were inconspicuous and allergic contact dermatitis was suspected. However, neither potential allergen nor irritant agent could be identified from anamnesis, and patch testing with European Baseline Series (Chemotechnique Diagnostics) produced negative results. Empirical treatment with topical 0.1% mometasone furoate (Elocom) for 2 weeks as well as topical 0.05% betamethasone dipropionate combined with 0.1% gentamicin (Bedicort G) for 2 weeks resulted in only temporal improvement.
Lesional skin scrapings were collected for bacterial and fungal culture. On MacConkey and Columbia agar with 5% sheep blood (Oxoid) no bacterial growth was observed. Whereas, on Sabouraud dextrose agar (SDA) with chloramphenicol and gentamicin as well as on SDA with chloramphenicol and cycloheximide (Graso), after 48-hour incubation at 30°C, smooth, creamy white, yeast-like colonies were...

View full text...
Reess M. Botanische Untersuchungen über die Alkoholgährungspilze. A. Leipzig, Felix 1870.
Kurtzman CP, Fell JW, Boekhout T. The Yeasts, a Taxonomic Study. Vol. 1. 5th ed. Elsevier, Amsterdam 2011.
Albertin W, Setati ME, Miot-Sertier C, et al. Hanseniaspora uvarum from winemaking environments show spatial and temporal genetic clustering. Front Microbiol 2016; 6: 1569.
Emmanouil-Nikoloussi E, Kanellaki-Kyparissi M, Papavassiliou P, et al. “Hanseniaspora uvarum” the ultrastructural morphology of a rare ascomycete, isolated from oral thrush. Bull. Group Int Rech Sci Stomatol Odontol 1994; 37: 13-7.
García-Martos P, Hernández-Molina JM, Galán F, et al. Isolation of Hanseniaspora uvarum (Kloeckera apiculata) in humans. Mycopathologia 1999; 144: 73-5.
Cendejas-Bueno E, Gomez-Lopez A, Mellado E, et al. Identification of pathogenic rare yeast species in clinical samples: comparison between phenotypical and molecular methods. J Clin Microbiol 2010; 48: 1895-9.
Severo Gomes B, Souza Motta CM, Lima AN, Porto ALF. Pathogenic characteristics of yeasts isolated from vaginal secretion preserved under mineral oil. J Venom Anim Toxins incl Trop Dis 2011; 17: 460-6.
Jagielski T, Rup E, Ziółkowska A, et al. Distribution of Malassezia species on the skin of patients with atopic dermatitis, psoriasis, and healthy volunteers assessed by conventional and molecular identification methods. BMC Dermatol 2014; 14: e3.
CLSI. Reference method for broth dilution antifungal susceptibility testing of yeasts; 3rd ed CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA 2008.
EUCAST Antifungal Agents, Breakpoint tables for interpretation of MICs v. 8.1 valid from 2017-03-01. European Committee on Antimicrobial Susceptibility Testing.
Schmalreck AF, Lackner M, Becker K, et al. Phylogenetic relationships matter: antifungal susceptibility among clinically relevant yeasts. Antimicrob Agents Chemother 2014; 58: 1575-85.
Pramateftaki PV, Kouvelis VN, Lanaridis P, Typas MA. The mitochondrial genome of the wine yeast Hanseniaspora uvarum: a unique genome organization among yeast/fungal counterparts. FEMS Yeast Res 2006; 6: 77-90.
Cadez N, Raspor P, de Cock AW, Boekhout T, Smith MT. Molecular identification and genetic diversity within species of the genera Hanseniaspora and Kloeckera. FEMS Yeast Res 2002; 1: 279-89.
Eddouzi J, Lohberger A, Vogne C, et al. Identification and antifungal susceptibility of a large collection of yeast strains isolated in Tunisian hospitals. Med Mycol 2013; 51: 737-46.
Batista AC, Coelho RP, Vieira JR. The incidence of Hanseniaspora valbyensis Kloecker in the human cecal appendix and epidermal lesions. Mycopathologia 1960; 12: 185-95.
Aksoycan N. The antigenic relationships between Hanseniaspora osmophila, H. uvarum and H. valbyensis strains. Mikrobiyol Bul 1982; 16: 107-10.
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe