Hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs in children

Agnieszka Szczukocka-Zych

doi:10.5114/pja.2019.88289

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

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3/2019
vol. 6

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abstract:

Review paper

Hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs in children

Agnieszka Szczukocka-Zych

¹

Klinika Pneumonologii i Alergologii Wieku Dziecięcego, Dziecięcy Szpital Kliniczny Uniwersyteckiego Centrum Klinicznego Warszawskiego Uniwersytetu Medycznego

Alergologia Polska – Polish Journal of Allergology 2019; 6, 3: 84–89

DOI: https://doi.org/10.5114/pja.2019.88289

Online publish date: 2019/10/07

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In addiction to antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs) are the most common group that cause adverse drug reactions in children. Part of these reactions are hypersensitivity reactions, among which selective (allergic) reactions and cross-hypersensitivity are distinguished. Each type of hypersensitivity manifests itself with characteristic clinical symptoms. In diagnostics, in addition to detailed medical history, skin prick tests and intradermal tests are important. The oral provocation test remains the gold standard used to exclude NSAIDs hypersensitivity. The article proposes a detailed diagnostic algorithm for children with suspected hypersensitivity. An important aspect is the development of alternative anti-inflammatory, analgesic and antipyretic therapy in patients with confirmed hypersensitivity to NSAIDs.

keywords:

Hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs in children

Agnieszka Szczukocka-Zych 1

non-steroidal anti-inflammatory drugs, hypersensitivity, children, drug allergy

Agnieszka Szczukocka-Zych

¹