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Health Problems of Civilization
eISSN: 2354-0265
ISSN: 2353-6942
Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
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abstract:
Original paper

IMPACT OF COMPREHENSIVE THERAPY ON GASTROINTESTINAL SYMPTOMS AND NUTRITIONAL STATUS IN ELDERLY PATIENTS WITH CHRONIC PANCREATITIS

Liliia Babinets
1
,
Nataliia Shevchenko
1, 2
,
Iryna Halabitska
1

  1. Department of Therapy and Family Medicine, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  2. Department of Occupational Pathology and Functional Diagnostics and Phthisiopulmonology Odesa National Medical University, Odesa, Ukraine
Health Prob Civil
Online publish date: 2025/02/26
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Background
Chronic pancreatitis is a progressive condition that impairs pancreatic function and is particularly challenging to manage in elderly patients.

Material and methods
The study included 59 elderly patients with chronic pancreatitis who were monitored by their primary care physician. Participants were divided into two groups: Group 1 (n=29), who received treatment according to a standard chronic pancreatitis management protocol, and Group 2 (n=30), who received the same standard treatment plus intracellular systemic enzyme therapy.

Results
Fecal α-elastase increased by 12.18% in Group 1 and 19.97% in Group 2, with Group 1 5.73% lower post-treatment (p<0.05). The Gastrointestinal Symptom Rating Scale (GSRS) scores showed greater reductions in Group 2, including abdominal pain (-39.04% vs. -30.53%) and indigestion (-31.83% vs. -26.39%) (p<0.05). Nutritional indicators improved more in Group 2, with higher total protein (+6.27% vs. +2.51%) and retinol levels (+57.58% vs. +28.13%) (p<0.05).

Conclusions
The study found that intracellular systemic enzyme therapy significantly improved outcomes in elderly patients with chronic pancreatitis, including improved fecal α-elastase levels and better coprogram and ultrasound scores. Additionally, the therapy led to notable improvements in gastrointestinal symptoms and biochemical markers, suggesting its potential as a beneficial addition to chronic pancreatitis management.

keywords:

intracellular systemic enzyme therapy, fecal α-elastase, GSRS, chronic pancreatitis, elderly patients


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