Health Problems of Civilization
eISSN: 2354-0265
ISSN: 2353-6942
Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
Current issue Archive Online first About the journal Editorial board Reviewers Abstracting and indexing Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
Share:
Send email
Share:
Review paper

IMPORTANCE OF SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO) IN THE ETIOPATHOGENESIS OF CHRONIC DISEASES

Agnieszka Sawina
1
,
Kinga Cogiel
1
,
Aleksandra Guzowska
1
,
Karolina Lau
1
,
Janusz Kasperczyk
1

  1. Chair and Department of Environmental Medicine and Epidemiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
Health Prob Civil.
DOI: https://doi.org/10.5114/hpc.2025.153881
Online publish date: 2025/10/02
Article file
- Sawina et al (1).pdf  [0.71 MB]
Get citation
 
PlumX metrics:
 
1. Roszkowska P, Klimczak E, Ostrycharz E, Rączka A, Wojciechowska-Koszko I, Dybus A, et al. Small intestinal bacterial overgrowth (SIBO) and twelve groups of related diseases—current state of knowledge. Biomedicines. 2024; 12(5): 1030. https://doi.org/10.3390/biomedicines12051030
2. Banaszak M, Górna I, Woźniak D, Przysławski J, Drzymała-Czyż S. Association between gut dysbiosis and the occurrence of SIBO, LIBO, SIFO and IMO. Microorganisms. 2023; 11(3): 573. https://doi.org/10.3390/microorganisms11030573
3. Suárez Terán J, Guarner Aguilar F. Small intestinal bacterial overgrowth (SIBO), a clinically overdiagnosed entity?. Gastroenterología y Hepatología (English Edition). 2024; 47(9): 502190. https://doi.org/10.1016/j.gastre.2024.502190
4. Crnčević N, Hukić M, Deumić S, Selimagić A, Dozić A, Gavrankapetanović I, et al. Gastrointestinal tract microbiome effect and role in disease development. Diseases. 2022; 10(3): 45. https://doi.org/10.3390/diseases10030045
5. Jensen BAH, Heyndrickx M, Jonkers D, Mackie A, Millet S, Naghibi M, et al. Small intestine vs. colon ecology and physiology: why it matters in probiotic administration. Cell Reports Medicine. 2023; 4(9): 101190. https://doi.org/10.1016/j.xcrm.2023.101190
6. Sroka N, Rydzewska-Rosołowska A, Kakareko K, Rosołowski M, Głowińska I, Hryszko T. Show me what you have inside—the complex interplay between sibo and multiple medical conditions—a systematic review. Nutrients. 2022; 15(1): 90. https://doi.org/10.3390/nu15010090
7. Maeda Y, Murakami T. Diagnosis by microbial culture, breath tests and urinary excretion tests, and treatments of small intestinal bacterial overgrowth. Antibiotics. 2023; 12(2): 263. https://doi.org/10.3390/antibiotics12020263
8. Beltrán-Velasco AI, Clemente-Suárez VJ. Harnessing gut microbiota for biomimetic innovations in health and biotechnology. Biomimetics. 2025; 10(2): 73. https://doi.org/10.3390/biomimetics10020073
9. Paul JK, Azmal M, Haque ASNB, Meem M, Talukder OF, Ghosh A. Unlocking the secrets of the human gut microbiota: Comprehensive review on its role in different diseases. World J Gastroenterol. 2025; 31(5). https://doi.org/10.3748/wjg.v31.i5.99913
10. Khalil M, Di Ciaula A, Mahdi L, Jaber N, Di Palo DM, Graziani A, et al. Unraveling the role of the human gut microbiome in health and diseases. Microorganisms. 2024; 12(11): 2333. https://doi.org/10.3390/microorganisms12112333
11. Park S. Special Issue: “Gut Microbiota and Nutrition in Human Health”. 2024; 25(21): 11589. https://doi.org/10.3390/ijms252111589
12. Chao J, Coleman RA, Keating DJ, Martin AM. Gut microbiome regulation of gut hormone secretion. Endocrinology. 2025; 166(4). https://doi.org/10.1210/endocr/bqaf004
13. Ross FC, Patangia D, Grimaud G, Lavelle A, Dempsey EM, Ross RP, et al. The interplay between diet and the gut microbiome: implications for health and disease. Nat Rev Microbiol. 2024; 22(11): 671-686. https://doi.org/10.1038/s41579-024-01068-4
14. Knez E, Kadac-Czapska K, Grembecka M. The importance of food quality, gut motility, and microbiome in SIBO development and treatment. Nutrition. 2024; 124: 112464. https://doi.org/10.1016/j.nut.2024.112464
15. Labetoulle M, Baudouin C, Benitez del Castillo JM, Rolando M, Rescigno M, Messmer EM, et al. How gut microbiota may impact ocular surface homeostasis and related disorders. Progress in Retinal and Eye Research. 2024; 100: 101250. https://doi.org/10.1016/j.preteyeres.2024.101250
16. Nikola L, Iva L. Gut microbiota as a modulator of type 1 diabetes: a molecular perspective. Life Sciences. 2024; 359: 123187. https://doi.org/10.1016/j.lfs.2024.123187
17. Yan K, Sun X, Fan C, Wang X, Yu H. Unveiling the role of gut microbiota and metabolites in autoimmune thyroid diseases: emerging perspectives. IJMS. 2024; 25(20): 10918. https://doi.org/10.3390/ijms252010918
18. Dalamaga M, Tsigalou C. Diet patterns, gut microbiota and metabolic disorders: perspectives and challenges. Metabolism Open. 2024; 23: 100310. https://doi.org/10.1016/j.metop.2024.100310
19. Wielgosz-Grochowska JP, Domanski N, Drywień ME. Identification of SIBO subtypes along with nutritional status and diet as key elements of SIBO therapy. IJMS. 2024; 25(13): 7341. https://doi.org/10.3390/ijms25137341
20. Alcedo González J, Estremera-Arévalo F, Cobián Malaver J, Santos Vicente J, Alcalá-González LG, Naves J, et al. Common questions and rationale answers about the intestinal bacterial overgrowth syndrome (SIBO). Gastroenterología y Hepatología (English Edition). 2025; 48(2): 502216. https://doi.org/10.1016/j.gastre.2024.502216
21. Skrzydło-Radomańska B, Cukrowska B. How to recognize and treat small intestinal bacterial overgrowth?. JCM. 2022; 11(20): 6017. https://doi.org/10.3390/jcm11206017
22. Souza C, Rocha R, Cotrim HP. Diet and intestinal bacterial overgrowth: is there evidence?. WJCC. 2022; 10(15): 4713-4716. https://doi.org/10.12998/wjcc.v10.i15.4713
23. Martyniak A, Wójcicka M, Rogatko I, Piskorz T, Tomasik PJ. A comprehensive review of the usefulness of prebiotics, probiotics, and postbiotics in the diagnosis and treatment of small intestine bacterial overgrowth. Microorganisms. 2025; 13(1): 57. https://doi.org/10.3390/microorganisms13010057
24. Bamba S, Imai T, Sasaki M, Ohno M, Yoshida S, Nishida A, et al. Altered gut microbiota in patients with small intestinal bacterial overgrowth. J of Gastro and Hepatol. 2022; 38(1): 61-69. http://doi.org/10.1111/jgh.16013
25. Zafar H, Jimenez B, Schneider A. Small intestinal bacterial overgrowth: current update. Current Opinion in Gastroenterology. 2023; 39(6): 522-528. https://doi.org/10.1097/MOG.0000000000000971
26. Wang Y, Qu Z, Chu J, Han S. Aging gut microbiome in healthy and unhealthy aging. Aging Dis. 2024; 16(2): 980‑1002. https://doi.org/10.14336/AD.2024.0331
27. Jennings T, Janquart M, Washak C, Duddleston K, Kurtz C. What’s gut got to do with it? The role of the microbiota and inflammation in the development of adiposity and obesity. Immunometabolism. 2023; 5(3): e00029. https://doi.org/10.1097/IN9.0000000000000029
28. Liébana-Castillo AR, Redondo-Cuevas L, Nicolás Á, Martín-Carbonell V, Sanchis L, Olivares A, et al. Should we treat SIBO patients? Impact on quality of life and response to comprehensive treatment: a real-world clinical practice study. Nutrients. 2025; 17(7): 1251. https://doi.org/10.3390/nu17071251
29. Losurdo G, D’Abramo FS, Indellicati G, Lillo C, Ierardi E, Di Leo A. the influence of small intestinal bacterial overgrowth in digestive and extra-intestinal disorders. IJMS. 2020; 21(10): 3531. https://doi.org/10.3390/ijms21103531
30. Goździewska M, Łyszczarz A, Kaczoruk M, Kolarzyk E. Relationship between SIBO and other bowel diseases and a common eating pattern for them. Part III. Ann Agric Environ Med. 2024; 31(3): 322-328. https://doi.org/10.26444/aaem/193103
31. Angelini G, Russo S, Mingrone G. Incretin hormones, obesity and gut microbiota. Peptides. 2024; 178: 171216. https://doi.org/10.1016/j.peptides.2024.171216
32. Efremova I, Maslennikov R, Poluektova E, Vasilieva E, Zharikov Y, Suslov A, et al. Epidemiology of small intestinal bacterial overgrowth. World J Gastroenterol. 2023; 29(22): 3400-3421. https://doi.org/10.3748/wjg.v29.i22.3400
33. Li Y, Liu X, Sun X, Li H, Wang S, Tian W, et al. Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration. Protein & Cell. 2024; 15(11): 818-839. https://doi.org/10.1093/procel/pwae016
34. Liang Y, Liu C, Cheng M, Geng L, Li J, Du W, et al. The link between gut microbiome and Alzheimer’s disease: from the perspective of new revised criteria for diagnosis and staging of Alzheimer’s disease. Alzheimer’s & Dementia. 2024; 20(8): 5771-5788. https://doi.org/10.1002/alz.14057
35. Zhou Q, Yang B, Zhu Y, Wang F, Tai Y, Liu Z, et al. Association of bacterial overgrowth in the small intestine with cortical thickness and functional connectivity in Parkinson’s disease involving mild cognitive impairment. Brain Imaging and Behavior. 2024; 18(6): 1509-1514. https://doi.org/10.1007/s11682-024-00948-w
36. Leta V, Klingelhoefer L, Longardner K, Campagnolo M, Levent HÇ, Aureli F, et al. Gastrointestinal barriers to levodopa transport and absorption in Parkinson’s disease. Euro J of Neurology. 2023; 30(5): 1465-1480. https://doi.org/10.1111/ene.15734
37. Chuah KH, Hian WX, Lim SZ, Beh KH, Mahadeva S. Impact of small intestinal bacterial overgrowth on symptoms and quality of life in irritable bowel syndrome. J of Digest Diseases. 2023; 24(3): 194-202. https://doi.org/10.1111/1751-2980.13189
38. Gong S, Zhang X, Chen X, Wan P, Zhou L, Zhang J. The impact of bariatric surgery on gut microbiota: a bibliometric analysis of research trends and scientific contributions. Front Microbiol. 2025; 16. https://doi.org/10.3389/fmicb.2025.1523809
39. Mollar A, Marrachelli VG, Núñez E, Monleon D, Bodí V, Sanchis J, et al. Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure. Sci Rep. 2021; 11(1). https://doi.org/10.1038/s41598-021-85527-5
40. Öz N, Gezer HH, Karabulut Y, Duruöz MT. Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study. Rheumatol Int. 2025; 45(1). https://doi.org/10.1007/s00296-024-05783-2
41. Daniluk A, Iwaniuk K, Wojda M, Świstowska M, Wielgosz A. Gut microbiota and thyroid diseases – summary of current knowledge. Qual Sport. 2024; 16: 52770. https://doi.org/10.12775/QS.2024.16.52770
42. Guertler A, Hering P, Pacífico C, Gasche N, Sladek B, Irimi M, et al. Characteristics of gut microbiota in rosacea patients—a cross-sectional, controlled pilot study. Life. 2024; 14(5): 585. https://doi.org/10.3390/life14050585
43. Wei F, Zhou L, Wang Q, Zheng G, Su S. Effect of compound lactic acid bacteria capsules on the small intestinal bacterial overgrowth in patients with depression and diabetes: a blinded randomized controlled clinical trial. Disease Markers. 2022; 2022: 1-6. https://doi.org/10.1155/2022/6721695
44. Bogielski B, Michalczyk K, Głodek P, Tempka B, Gębski W, Stygar D. Association between small intestine bacterial overgrowth and psychiatric disorders. Front Endocrinol. 2024; 15. https://doi.org/10.3389/fendo.2024.1438066
45. Sowmiya S, Dhivya LS, Rajendran P, Harikrishnan N, Singh AS. Exploring the potential of probiotics in Alzheimer’s disease and gut dysbiosis. IBRO Neuroscience Reports. 2024; 17: 441-455. https://doi.org/10.1016/j.ibneur.2024.11.004
46. Kossewska J, Bierlit K, Trajkovski V. Personality, anxiety, and stress in patients with small intestine bacterial overgrowth syndrome. The Polish preliminary study. IJERPH. 2022; 20(1): 93. https://doi.org/10.3390/ijerph20010093
47. Feng X, Hu J, Zhang X. Prevalence and predictors of small intestinal bacterial overgrowth in inflammatory bowel disease: a meta-analysis. Front Med. 2025; 11. https://doi.org/10.3389/fmed.2024.1490506
48. Wilk K, Witkowska E, Ciechański M, Cholewiński S, Wilk B, Stachura P, et al. Understanding SIBO: a comprehensive review of causes, symptoms, diagnosis and treatment strategies of small intestinal bacterial overgrowth. J Educ Health Sport. 2025; 82: 60508. https://doi.org/10.12775/JEHS.2025.82.60508
49. Sharabi E, Rezaie A. Small intestinal bacterial overgrowth. Curr Infect Dis Rep. 2024; 26(11): 227-33. https://doi.org/10.1007/s11908-024-00847-7
50. Nowakowski K, Mularczyk Z, Reclik M, Oleksy P, Tenderenda M. Small intestinal bacterial overgrowth syndrome: new clinical insights for multimorbid and high-risk patients. Qual Sport. 2024; 36: 56729. https://doi.org/10.12775/QS.2024.36.56729
Copyright: © 2025 Pope John Paul II State School of Higher Education in Biała Podlaska. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2025 Termedia Sp. z o.o.
Developed by Bentus.