eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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3/2021
vol. 59
 
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abstract:
Original paper

Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells

Zhuo Zhang
1
,
Shu-Zhen Yang
2
,
You-Fu Qi
3
,
Yong Yin
4

1.
Neurology Department, Liaocheng Second People’s Hospital, Liaocheng, Shandong, China
2.
The Second People’s Hospital of Shenxian County, Shenxian, Shandong, China
3.
Department of Neurology, Ward 2, Linqing People’s Hospital, Linqing, Shandong, China
4.
Department of Neurology, Ward 4, People’s Hospital of Pingyi County, Pingyi, Shandong, China
Folia Neuropathol 2021; 59 (3): 239-248
Online publish date: 2021/10/05
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Increasing evidence highlights that microRNAs (miRNAs) drive glioma initiation and development. Nevertheless, the underlying role of miR-21-5p in glioma is elusive. Hence, we evaluated the underlying role of miR-21-5p in glioma progression. Microarray data analysis provided data indicating that the miR-21-5p level was elevated in glioma. Silenced miR-21-5p suppressed glioma cell growth and invasion. Additionally, our results disclosed that ten-eleven translocation 1 (TET1) was directly targeted by miR-21-5p. Furthermore, antagomir-21-5p restrained glioma cell growth in a xenograft tumour model. In rescue experiments, knockdown of TET1 neutralized miR-21-5p silence-mediated inhibitory function on glioma cell aggressiveness. Taken together, miR-21-5p exerted its carcinogenic effect in glioma cell growth and invasin by targeting TET1.
keywords:

glioma, proliferation, invasion, MiR-21-5p, TET1

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