Abstract
Improved disease-free survival with adjuvant radiotherapy in early-stage endometrial cancer: 10-year outcome analysis
- Department of Radiation Oncology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
- Department of Radiation Oncology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
- Department of Radiation Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
- Department of Radiation Oncology, Ankara Memorial Hospital, Ankara, Turkey
Purpose
The purpose of this study was to evaluate long-term treatment outcomes and prognostic factors affecting survival of patients with early-stage endometrial carcinoma.
Material and methods
Data of 311 patients with FIGO stage I-II endometrial cancer, curatively treated at two different tertiary centers between June 2001 and December 2016 were retrospectively reviewed. The patients had primary surgery, 74 (24%) received no further treatment, 4 (1%) obtained chemotherapy only, 234 (75%) received radiotherapy, and 24 (7%) received both.
Results
Median follow-up time was 102 (range, 3-205) months. During this period, 68 (21.9%) patients died. 5-year and 10-year disease-free survival (DFS) were 76% and 74.3%, respectively. In multivariate analysis, lower uterine segment invasion positivity and no adjuvant radiotherapy were determined as independent unfavorable prognostic factors for DFS. The 5-year and 10-year disease-specific survival (DSS) were 86.8% and 82.2%, respectively. For DSS, high-grade, lymphovascular space invasion positivity, stage II, ≥ 65 age, and no adjuvant radiotherapy were found to be independent unfavorable prognostic markers.
Conclusions
The findings of our cohort have confirmed the importance of adjuvant radiotherapy on long-term early-stage endometrial carcinoma outcome.
Keywords
early-stage endometrium cancer, adjuvant therapy, radiotherapy, survival
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