eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
 
3/2022
vol. 60
 
Share:
Share:
more
 
 
abstract:
Review paper

Incidence and morphology of secondary TDP-43 proteinopathies: Part 1

Albert Acewicz
1
,
Tomasz Stępień
1
,
Paulina Felczak
1
,
Sylwia Tarka
2
,
Teresa Wierzba-Bobrowicz
1

1.
Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
2.
Department of Forensic Medicine, Medical University of Warsaw, Warsaw, Poland
Folia Neuropathol 2022; 60 (3): 267-276
Online publish date: 2022/11/03
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
PlumX metrics:
Transactive response DNA binding protein of 43 kDa (TDP-43) is considered to play an essential role in the pathogenesis of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Growing body of evidence indicate that pathological TDP-43 inclusions frequently occur in the context of other distinctive hallmark pathologies, referred to as secondary

TDP-43 proteinopathies. Comorbid TDP-43 pathology is well-documented in several neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, multiple system atrophy, or progressive supranuclear palsy. It may also appear as a consequence of less obvious disease etiologies, i.e. post-traumatic (chronic traumatic encephalopathy), neoplastic (pilocytic astrocytoma), or post-infectious (post-encephalitic parkinsonism). The aim of the present review was to evaluate the incidence, morphology, and role of TDP-43 pathology in the secondary TDP-43 proteinopathies. This article (Part 1) discussed TDP-43 pathology in more common neurodegenerative diseases, including Alzheimer’s disease, Lewy body disease, Huntington’s disease, multiple system atrophy, corticobasal degeneration, and progressive supranuclear palsy. A follow-up article (Part 2) will describe abnormal TDP-43 changes in rare neurodegenerative diseases or neurological diseases with nondegenerative etiology.
keywords:

TDP-43, pathology, proteinopathy, neurodegenerative, morphology, incidence, comorbidity

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.