en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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2/2011
vol. 49
 
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abstract:
Review paper

Influence of leptin and adiponectin on chondrogenesis and osteoblastogenesis. A potential role in rheumatoid arthritis pathogenesis

Urszula Skalska
,
Ewa Kontny

Reumatologia 2011; 49, 2: 126–131
Online publish date: 2011/05/06
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Leptin and adiponectin are classic adipokines produced in the white adipose tissue. They exert pleiotropic effects on organism and currently their role in rheumatoid arthritis and osteoarthritis is intensively studied. The role of adiponectin and leptin in chondrogenesis and osteogenesis is still unclear. These processes are crucial in rheumatoid arthritis because of massive destruction of joint cartilage and bone in this disease. The influence of these two adipokines must be elucidated as well as their influence on differentiation of mesenchymal stem cells. In this article we present current knowledge on adiponectin and leptin influence on chondrogenesis and osteoblastogenesis (Table I, II).
keywords:

adiponectin, chondrogenesis, leptin, osteoblastogenesis, rheumatoid arthritis







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