eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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SCImago Journal & Country Rank
1/2021
vol. 59
 
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abstract:
Original paper

Inhibition of ASC enhances the protective role of salvianolic acid A in traumatic brain injury via inhibition of inflammation and recovery of mitochondrial function

Jing Wang
1
,
Chao Xu
2
,
Kunhu Zhang
3
,
Jianjun Shi
1
,
Zhenyang Liu
1
,
Xinxing Wang
1
,
Min Guo
1
,
Jiannan Lv
4
,
Xinmin Ding
1

1.
Department of Neurosurgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, The Third Affiliated Hospital of Shanxi Medical University, Taiyuan, China
2.
Department of Neurosurgery, Shanxi Corps Hospital of PAP, Taiyuan, China
3.
Department of Neurosurgery, Baoji Hitech People’s Hospital, Baoji, China
4.
Ultrasonic Department, Characteristic Medical Centre of PAP, Tianjin, China
Folia Neuropathol 2021; 59 (1): 50-66
Online publish date: 2021/03/31
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More than 50 million people are affected by traumatic brain injury (TBI) each year around the world, and nearly half of the population worldwide will have one or more TBI(s) in their lifetime. And in 2017, more than 1.39 billion people in China suffered from TBI, representing nearly 18% of the world population; these were mainly caused by road traffic incidents. Salvianolic acid A is a compound obtained from Salvia miltiorrhiza Bunge, which is one of the active components of many traditional Chinese medicines for the treatment of cardiovascular and cerebrovascular disease, with the effect of inhibition of inflammatory response. ASC is a critical factor in the activation of inflammation response process via promoting the maturation of caspase-1, and activation of NLPR3 under bacterial infection promotes the necrosis of cells in an ASC-dependent manner. However, few studies focus on the effect of ASC in a TBI model. In this study, we found that inhibition of ASC reduced the expression of inflammatory cytokines, and the concentration of calcium and ROS, while it increased the expression of mitochondrial function-related proteins. We further noticed that these effects were regulated by DLK2/MLK3/JNK signalling pathway and might contribute to the treatment of TBI.
keywords:

ASC, salvianolic acid A, traumatic brain injury, inflammation, mitochondria, signalling pathway

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