Folia Neuropathologica

Full text

3/2026 vol. 64
Review paper

Integrating diagnosis, classification, and multimodal management in epilepsy care

  1. Department of Neurology, Weihai Municipal Hospital, Huancui District, Weihai City, Shandong Province, 264200, China

  2. Department of Hematology, Weihai Central Hospital, Wendeng District, Weihai City, Shandong Province, 264400, China

Folia Neuropathol 2026; 64 (3): 225-239

Data publikacji online: 2026/10/23
Article file
FN Integrating.pdf
  1. Ali A. Global health: Epilepsy. Semin Neurol 2018; 38: 191-199.
  2. Ali Arazeem A, Tahirah Adedolapo I, Joseph Alabi O. Shame, stigma, and social exclusion: The lived experiences of epileptic patients in a health facility in Ilorin, Nigeria. Glob Public Health 2022; 17: 3839-3852.
  3. Amiri S, Arbabi M, Rahimi M, Badragheh F, Zibadi HA, Asadi- Pooya AA, Mirbagheri MM. Effective connectivity between emotional and motor brain regions in people with psychogenic nonepileptic seizures (PNES). Epilepsy Behav 2021; 122: 108085.
  4. Arango MF, Steven DA, Herrick IA. Neurosurgery for the treatment of epilepsy. Curr Opin Anaesthesiol 2004; 17: 383-387.
  5. Arzimanoglou A, Brandl U, Cross JH, Gil-Nagel A, Lagae L, Landmark CJ, Specchio N, Nabbout R, Thiele EA, Gubbay O, The Cannabinoids International Experts Panel; Collaborators. Epilepsy and cannabidiol: a guide to treatment. Epileptic Disord 2020; 22: 1-14.
  6. Assuah FB, Emanuel B, Lacasse BM, Beggs J, Lou J, Motta FC, Nemzer LR, Worth R, Cravens GD. A literature review of similarities between and among patients with autism spectrum disorder and epilepsy. Cureus 2023; 15: e33946.
  7. Bauer PR, Bronnec MLA, Schulze-Bonhage A, Altenmüller DM, Fuchs T. Seizures as a struggle between life and death: an existential approach to the psychosocial impact of seizures in candidates for epilepsy surgery. Psychopathology 2023; 56: 417-429.
  8. Beghi E, Giussani G, Sander JW. The natural history and prognosis of epilepsy. Epileptic Disord 2015; 17: 243-253.
  9. Beniczky S, Trinka E, Wirrell E, Abdulla F, Al Baradie R, Alonso Vanegas M, Auvin S, Singh MB, Blumenfeld H, Bogacz Fressola A, Caraballo R, Carreno M, Cendes F, Charway A, Cook M, Craiu D, Ezeala-Adikaibe B, Frauscher B, French J, Gule MV, Higurashi N, Ikeda A, Jansen FE, Jobst B, Kahane P, Kishk N, Khoo CS, Vinayan KP, Lagae L, Lim KS, Lizcano A, McGonigal A, Perez-Gosiengfiao KT, Ryvlin P, Specchio N, Sperling MR, Stefan H, Tatum W, Tripathi M, Yacubian EM, Wiebe S, Wilmshurst J, Zhou D, Cross JH. Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy. Epilepsia 2025; 66: 1804-1823.
  10. Bingaman N, Ferguson L, Thompson N, Reyes A, McDonald CR, Hermann BP, Arrotta K, Busch RM. The relationship between mood and anxiety and cognitive phenotypes in adults with pharmacoresistant temporal lobe epilepsy. Epilepsia 2023; 64: 3331-3341.
  11. Błaszczyk B, Czuczwar SJ. Epilepsy coexisting with depression. Pharmacol Rep 2016; 68: 1084-1092.
  12. Borowicz-Reutt K, Krawczyk M, Czernia J. Ketogenic diet in the treatment of epilepsy. Nutrients 2024; 16: 1258.
  13. Bush NE, Greyson B. Distressing near-death experiences: the basics. Mo Med 2014; 111: 486-490.
  14. Chaudhuri KR, Healy DG, Schapira AH; National Institute for Clinical Excellence. Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol 2006; 5: 235-245.
  15. Chen Z, Brodie MJ, Liew D, Kwan P. Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new anti-epileptic drugs: A 30-year longitudinal cohort study. JAMA Neurol 2018; 75: 279-286.
  16. Chirra M, Marsili L, Gallerini S, Keeling EG, Marconi R, Colosimo C. Paraneoplastic movement disorders: phenomenology, diagnosis, and treatment. Eur J Intern Med 2019; 67: 14-23.
  17. Collard SS, Hardman D. “I don’t know enough about epilepsy”: experiences and perspectives of sport and fitness professionals on training adults with epilepsy. Epilepsy Behav 2025; 172: 110681.
  18. Corsello A, Marangoni MB, Macchi M, Cozzi L, Agostoni C, Mila- ni GP, Dilena R. Febrile Seizures: A Systematic Review of Different Guidelines. Pediatr Neurol 2024; 155: 141-148.
  19. Damis LF. The role of implicit memory in the development and recovery from trauma-related disorders. NeuroSci 2022; 3: 63-88.
  20. Datta AN. A video case vignette: Hypermotor activity, ictal aggression, and bolting in an adolescent with an anteromedial temporal lesion. Epileptic Disord 2024; 26: 236-239.
  21. Deschamps A, Ben Abdallah A, Jacobsohn E, Saha T, Djaiani G, El-Gabalawy R, Overbeek C, Palermo J, Courbe A, Cloutier I, Tanzola R, Kronzer A, Fritz BA, Schmitt EM, Inouye SK, Avidan MS; Canadian Perioperative Anesthesia Clinical Trials Group. Electroencephalography-guided anesthesia and delirium in older adults after cardiac surgery: The ENGAGES-Canada Randomized Clinical Trial. JAMA 2024; 332: 112-123.
  22. Devigili G, Di Stefano G, Donadio V, Frattale I, Grazzi L, Mantova- ni E, Nolano M, Provitera V, Quitadamo SG, Tamburin S, Truini A, Valeriani M, Furia A, Vecchio E, Fischetti F, Greco G, Telesca A, de Tommaso M; On behalf of neuropathic pain special interest group of the Italian neurological society (sin). Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society. Neurol Sci 2025; 46: 2263-2288.
  23. Devinsky O, Vezzani A, O’Brien TJ, Jette N, Scheffer IE, de Curtis M, Perucca P. Epilepsy. Nat Rev Dis Primers 2018; 4: 18024.
  24. Dimakopoulos V, Gotman J, Klimes P, von Ellenrieder N, Tan SB, Smith G, Gliske SV, Maltseva M, Manalo MK, Pail M, Brazdil M, van Blooijs D, van ‘t Klooster MA, Johnson S, Laboy S, Ledergerber D, Imbach L, Papadelis C, Sperling MR, Zijlmans M, Cimbalnik J, Jacobs J, Stacey WC, Frauscher B, Sarnthein J. Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations. Brain 2025; 148: 1769-1777.
  25. Dimopoulos MA, Terpos E, Boccadoro M, Moreau P, Mateos MV, Zweegman S, Cook G, Engelhardt M, Delforge M, Hajek R, Schjesvold F, Gay F, Manier S, Weisel KC, Kaiser M, van de Donk NWCJ, Zamagni E, Rodriguez-Otero P, Perrot A, Driessen C, Bila J, Laane E, Dytfeld D, Touzeau C, Beksac M, Raab MS, Cavo M, Mohty M, Spencer A, Ludwig H, Einsele H, San-Miguel J, Sonneveld P. EHA-EMN Evidence-Based Guidelines for diagnosis, treatment and follow-up of patients with multiple myeloma. Nat Rev Clin Oncol 2025; 22: 680-700.
  26. Dudley P, Marquez JP, Farrell F, Benson J, Rugg-Gunn F, Sidhu MK, O’Sullivan S, Walker M, Yogarajah M. Functional seizures and their mimics: a retrospective service review of cases from a tertiary video telemetry database. BMJ Neurol Open 2024; 6: e000738.
  27. Dzah SS, Owusu DAM, der Wath AV, Abraham SA, Amoadu M, Leech R. Strategies utilized and challenges faced by stakeholders while managing epilepsy in African schools: A scoping review. Epilepsy Behav 2025; 171: 110612.
  28. Falco-Walter J. Epilepsy – definition, classification, pathophysiology, and epidemiology. Semin Neurol 2020; 40: 617-623.
  29. Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J. Alzheimer disease and epilepsy: A mendelian randomization study. Neurology 2023; 101: e399-e409.
  30. Fantini S, Sassaroli A, Tgavalekos KT, Kornbluth J. Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods. Neurophotonics 2016; 3: 031411.
  31. Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N. Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology 2017; 88: 296-303.
  32. Forsgård JA, Metsähonkala L, Kiviranta AM, Cizinauskas S, Junnila JJT, Laitinen-Vapaavuori O, Jokinen TS. Seizure-precipitating factors in dogs with idiopathic epilepsy. J Vet Intern Med 2019; 33: 701-707.
  33. Fotiadis P, Parkes L, Davis KA, Satterthwaite TD, Shinohara RT, Bassett DS. Structure-function coupling in macroscale human brain networks. Nat Rev Neurosci 2024; 25: 688-704.
  34. Garg I, Verma M, Kumar H, Maurya R, Negi T, Jain P. Bioelectronic therapeutics: A revolutionary medical practice in health care. Bioelectricity 2025; 7: 2-28.
  35. Gebien DJ, Eisenhut M. Uncovering diaphragm cramp in SIDS and other sudden unexpected deaths. Diagnostics (Basel) 2024; 14: 2324.
  36. Geenen KR, Patel S, Thiele EA. Sunflower syndrome: a poorly understood photosensitive epilepsy. Dev Med Child Neurol 2021; 63: 259-262.
  37. Ghoshal S. Neurologic complications of critical illness. Continuum (Minneap Minn) 2026; 32: 191-210.
  38. González Otárula KA, Schuele S. Networks in temporal lobe epilepsy. Neurosurg Clin N Am 2020; 31: 309-317.
  39. Goodman AM, Szaflarski JP. Recent advances in neuroimaging of epilepsy. Neurotherapeutics 2021; 18: 811-826.
  40. Greenfield MJ, Fobian AD, Fargason RE, Birur B. Optimizing outcomes when treating functional neurological disorder in acute care settings: case reports depicting the value of diagnostic precision and timely and appropriate psychological interventions using an interdisciplinary framework. Front Psychiatry 2024; 15: 1288828.
  41. Greer DM, Kirschen MP, Lewis A, Gronseth GS, Rae-Grant A, Ashwal S, Babu MA, Bauer DF, Billinghurst L, Corey A, Partap S, Rubin MA, Shutter L, Takahashi C, Tasker RC, Varelas PN, Wijdicks E, Bennett A, Wessels SR, Halperin JJ. Pediatric and adult brain death/death by neurologic criteria consensus guideline. Neurology 2023; 101: 1112-1132.
  42. Harkin LA, McMahon JM, Iona X, Dibbens L, Pelekanos JT, Zuberi SM, Sadleir LG, Andermann E, Gill D, Farrell K, Connolly M, Stanley T, Harbord M, Andermann F, Wang J, Batish SD, Jones JG, Seltzer WK, Gardner A; Infantile Epileptic Encephalopathy Referral Consortium; Sutherland G, Berkovic SF, Mulley JC, Scheffer IE. The spectrum of SCN1A-related infantile epileptic encephalopathies. Brain 2007; 130: 843-852.
  43. Hirsch LJ, Fong MWK, Leitinger M, LaRoche SM, Beniczky S, Abend NS, Lee JW, Wusthoff CJ, Hahn CD, Westover MB, Gerard EE, Herman ST, Haider HA, Osman G, Rodriguez-Ruiz A, Maciel CB, Gilmore EJ, Fernandez A, Rosenthal ES, Claassen J, Husain AM, Yoo JY, So EL, Kaplan PW, Nuwer MR, van Putten M, Sutter R, Drislane FW, Trinka E, Gaspard N. American Clinical Neurophysiology Society’s standardized critical care EEG terminology: 2021 Version. J Clin Neurophysiol 2021; 38: 1-29.
  44. Jones S, Angus-Leppan H. Mind the Gap! What do people with epilepsy want to know? Epilepsy Behav 2026; 175: 110861.
  45. Kale MB, Umare MD, Wankhede NL, Deshmukh R, Abbot V, Anwer MK, Taksande BG, Upaganlawar AB, Umekar MJ, Ramniwas S, Gulati M, Arora R, Behl T. Decoding the therapeutic potential of cannabis and cannabinoids in neurological disorders. Curr Pharm Des 2025; 31: 630-644.
  46. Ketata I, Ellouz E, Mizouri R. Impact of prenatal, neonatal, and postnatal factors on epilepsy risk in children and adolescents: a systematic review and meta-analysis. Acta Epileptol 2024; 6: 1.
  47. Kratzer I, Liddelow SA, Saunders NR, Dziegielewska KM, Strazielle N, Ghersi-Egea JF. Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection. Fluids Barriers CNS 2013; 10: 25.
  48. Kumari P, Ram D, Haque Nizamie S, Goyal N. Stigma and quality of life in individuals with epilepsy: a preliminary report. Epilepsy Behav 2009; 15: 358-361.
  49. Lai CC, Wang CY, Wang YH, Hsueh SC, Ko WC, Hsueh PR. Global epidemiology of coronavirus disease 2019 (COVID-19): disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status. Int J Antimicrob Agents 2020; 55: 105946.
  50. Lee HM, Fadaie F, Gill RS, Caldairou B, Sziklas V, Crane J, Hong SJ, Bernhardt BC, Bernasconi A, Bernasconi N. MRI-derived modeling of disease progression patterns in patients with temporal lobe epilepsy. Neurology 2024; 103: e209524.
  51. Leibetseder A, Eisermann M, LaFrance WC Jr, Nobili L, von Oertzen TJ. How to distinguish seizures from non-epileptic manifestations. Epileptic Disord 2020; 22: 716-738.
  52. Li C, Wang X, Deng M, Luo Q, Yang C, Gu Z, Lin S, Luo Y, Chen L, Li Y, He B. Anti-epileptic drug combinations for epilepsy: mechanisms, clinical strategies, and future prospects. Int J Mol Sci 2025; 26: 4035.
  53. Li P, Lin J, Wu C, Huang S, Zhu S. The impact of social factors, especially psychological worries on anxiety and depression in patients with epilepsy. Epilepsy Behav 2021; 125: 108376.
  54. Lin CH, Cheng MY, Tseng WJ, Chang CW, Lee CH, Wu T, Chiang HI, Liao TW, Lin WR, Liu CJ, Chen PR, Lim SN. Clinical profiles and prognostic factors in reflex epilepsy: Insights from a Taiwanese cohort. Seizure 2025; 124: 39-47.
  55. Liu J, Wang G, Shi M, Guo RY, Yuan C, Wang Y, Mehmood A, Zhang L, Li B. BTK and YKL-40 Levels and their association with acute AQP4-IgG-positive neuromyelitis optica spectrum disorder. Mol Neurobiol 2025; 62: 4785-4801.
  56. Liu J, Zhang P, Zou Q, Liang J, Chen Y, Cai Y, Li S, Li J, Su J, Li Q. Status of epilepsy in the tropics: An overlooked perspective. Epilepsia Open 2023; 8: 32-45.
  57. Luo Z, Wang N. Effects of intervention strategies-based on positive psychology on the emotional cognition, mental health, and recovery of speech function in speech disabilities. Iran J Public Health 2024; 53: 1068-1076.
  58. Machegger L, Bosque Varela P, Crespo Pimentel B, Kuchukhidze G. Connectomes in temporal lobe and idiopathic generalized epilepsies. J Clin Med 2025; 14: 3744.
  59. Marinescu SCN, Apetroaei MM, Nedea MII, Arsene AL, Velescu BȘ, Hîncu S, Stancu E, Pop AL, Drăgănescu D, Udeanu DI. Dietary influence on drug efficacy: a comprehensive review of ketogenic diet-pharmacotherapy interactions. Nutrients 2024; 16: 1213.
  60. Martín-Rodríguez A, Gostian-Ropotin LA, Beltrán-Velasco AI, Belando-Pedreño N, Simón JA, López-Mora C, Navarro-Jiménez E, Tornero-Aguilera JF, Clemente-Suárez VJ. Sporting mind: the interplay of physical activity and psychological health. Sports (Basel) 2024; 12: 37.
  61. Mehmood A, Ali W, Din ZU, Song S, Sohail M, Shah W, Guo J, Guo RY, Ilahi I, Shah S, Al-Shaebi F, Zeb L, Asiamah EA, Al-Dhamin Z, Bilal H, Li B. Clustered regularly interspaced short palindromic repeats as an advanced treatment for Parkinson’s disease. Brain Behav 2021; 11: e2280.
  62. Mehmood A, Ali W, Song S, Din ZU, Guo RY, Shah W, Ilahi I, Yin B, Yan H, Zhang L, Khan M, Ali W, Zeb L, Safari H, Li B. Optical coherence tomography monitoring and diagnosing retinal changes in multiple sclerosis. Brain Behav 2021; 11: e2302.
  63. Mehmood A, Din M, Munawer M, Shah S, Liu X, Jiang H, Wang X. Neuroectodermal interleukin 12 signaling attenuates spinal cord inflammation and demyelination. Folia Neuropathol 2026; 64: 63-72.
  64. Mehmood A, Shah S, Guo RY, Haider A, Shi M, Ali H, Ali I, Ullah R, Li B. Methyl-CpG-binding protein 2 emerges as a central player in multiple sclerosis and neuromyelitis optica spectrum disorders. Cell Mol Neurobiol 2023; 43: 4071-4101.
  65. Mehmood A, Song S, Du X, Yan H, Wang X, Guo L, Li B. mRNA expression profile reveals differentially expressed genes in splenocytes of experimental autoimmune encephalomyelitis model. Int J Exp Pathol 2023; 104: 247-257.
  66. Mesraoua B, Koepp M, Schuknecht B, Deleu D, Al Hail HJ, Melikyan G, Elsheikh L, Asadi-Pooya AA. Unexpected brain imaging findings in patients with seizures. Epilepsy Behav 2020; 111: 107241.
  67. Miao M, Han Y, Zhang Y, Xu Y, Zhang L, Yang Y, Sun M, Zhang J. Epileptiform EEG discharges during sevoflurane anesthesia in children: A meta-analysis. Clin Neurophysiol 2022; 143: 48-55.
  68. Milligan TA. Epilepsy: A clinical overview. Am J Med 2021; 134: 840-847.
  69. Montalban X, Gold R, Thompson AJ, Otero-Romero S, Amato MP, Chandraratna D, Clanet M, Comi G, Derfuss T, Fazekas F, Hartung HP, Havrdova E, Hemmer B, Kappos L, Liblau R, Lubetzki C, Marcus E, Miller DH, Olsson T, Pilling S, Selmaj K, Siva A, Sorensen PS, Sormani MP, Thalheim C, Wiendl H, Zipp F. ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis. Mult Scler 2018; 24: 96-120.
  70. Myers KA. Genetic epilepsy syndromes. Continuum (Minneap Minn) 2022; 28: 339-362.
  71. Numis AL, Glass HC, Soul JS, Wusthoff CJ, Massey SL, Benedetti GM, Chu CJ, Thomas C, Anwar T, Lemmon ME, Franck LS, Berl MM, Pilon B, Rau SMD, Li Y, Sturza J, McCulloch CE, Shellhaas RA. Postneonatal epilepsy after acute provoked neonatal seizures: Incidence, predictors, and clinical burden in a multicenter cohort followed through early childhood. Epilepsia 2025; 66: 4844-4856.
  72. Odhiambo M, Kariuki SM, Newton CR. Therapeutic monitoring of anti-seizure medications in low- and middle-income countries: a systematic review. Wellcome Open Res 2024; 6: 92.
  73. Paungarttner J, Quartana M, Patti L, Sklenárová B, Farham F, Jiménez IH, Soylu MG, Vlad IM, Tasdelen S, Mateu T, Marsico O, Reina F, Tischler V, Lampl C; European Headache Federation School of Advanced Studies (EHF – SAS). Migraine – a borderland disease to epilepsy: near it but not of it. J Headache Pain 2024; 25: 11.
  74. Pellinen J. Treatment gaps in epilepsy. Front Epidemiol 2022; 2: 976039.
  75. Peña-Zelayeta L, Delgado-Minjares KM, Villegas-Rojas MM, León-Arcia K, Santiago-Balmaseda A, Andrade-Guerrero J, Pérez-Segura I, Ortega-Robles E, Soto-Rojas LO, Arias-Carrión O. Redefining non-motor symptoms in Parkinson’s disease. J Pers Med 2025; 15: 172.
  76. Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I. Sustained survival benefit in recurrent medulloblastoma by a metronomic antiangiogenic regimen: a nonrandomized controlled trial. JAMA Oncol 2023; 9: 1688-1695.
  77. Pressler RM, Cilio MR, Mizrahi EM, Moshé SL, Nunes ML, Plouin P, Vanhatalo S, Yozawitz E, de Vries LS, Puthenveettil Vinayan K, Triki CC, Wilmshurst JM, Yamamoto H, Zuberi SM. The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures. Epilepsia 2021; 62: 615-628.
  78. Puteikis K, Mameniškienė R. Mortality among people with epilepsy: A retrospective nationwide analysis from 2016 to 2019. Int J Environ Res Public Health 2021; 18: 10512.
  79. Rastin C, Schenkel LC, Sadikovic B. Complexity in genetic epilepsies: A comprehensive review. Int J Mol Sci 2023; 24: 14606.
  80. Recino A, Rayner MLD, Rohn JL, Della Pasqua O; UCL Repurposing TIN Committee. Therapeutic innovation in drug repurposing: Challenges and opportunities. Drug Discov Today 2025; 30: 104390.
  81. Reddy DS, Vadassery A, Ramakrishnan S, Singh T, Clossen B, Wu X. Kindling models of epileptogenesis for developing disease-modifying drugs for epilepsy. Curr Protoc 2024; 4: e70020.
  82. Saade D, Joshi C. Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report. Pediatr Neurol 2015; 52: 544-547.
  83. Samanta D. Cannabidiol: a review of clinical efficacy and safety in epilepsy. Pediatr Neurol 2019; 96: 24-29.
  84. Samanta D. Epilepsy in Angelman syndrome: A scoping review. Brain Dev 2021; 43: 32-44.
  85. Schachter SC. Seizure disorders. Med Clin North Am 2009; 93: 343-351.
  86. Schüssler SC, Paul A, Niederreiter U, Deiters L, Fahlbusch FB, Morhart P, Trollmann R. Seizures in preterm infants with germinal-matrix-intraventricular hemorrhage (GM-IVH): a retrospective monocentric study on predictors and neurodevelopmental outcome. Eur J Paediatr Neurol 2025; 56: 51-57.
  87. Sen A, Jette N, Husain M, Sander JW. Epilepsy in older people. Lancet 2020; 395: 735-748.
  88. Shum J, Friedman D. Commercially available seizure detection devices: A systematic review. J Neurol Sci 2021; 428: 117611.
  89. Singh K, Malhotra J. Deep learning based smart health monitoring for automated prediction of epileptic seizures using spectral analysis of scalp EEG. Phys Eng Sci Med 2021; 44: 1161-1173.
  90. Song S, Guo R, Mehmood A, Zhang L, Yin B, Yuan C, Zhang H, Guo L, Li B. Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway. CNS Neurosci Ther 2022; 28: 422-434.
  91. Sonneville R, Benghanem S, Jeantin L, de Montmollin E, Doman M, Gaudemer A, Thy M, Timsit JF. The spectrum of sepsis-associated encephalopathy: a clinical perspective. Crit Care 2023; 27: 386.
  92. Specchio N, Wirrell EC, Scheffer IE, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi SM, Wilmshurst JM, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross HJ, Perucca E, Moshé SL, Tinuper P, Auvin S. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia 2022; 63: 1398-1442.
  93. Spurgeon E, Saper R, Alexopoulos A, Allendorfer JB, Bar J, Caldwell J, Cervenka M, Darling S, Dombrowski S, Gallagher L, Lazar S, Modlo E, Perko J, Sajatovic M, Tilahun B, Yardi N, Najm I. Proceedings of the 2022 “Lifestyle Intervention for Epilepsy (LIFE)” symposium hosted by Cleveland Clinic. Epilepsia Open 2024; 9: 1981-1996.
  94. Su S, Zhang H, Zhang Q, Zhao F, Hu W, Liu Y, Fang F. Genotypic and phenotypic analysis of epilepsy associated with NPRL2/NPRL3 genes. Seizure 2025; 133: 208-218.
  95. Tautan AM, Andrei AG, Smeralda CL, Vatti G, Rossi S, Ionescu B. Unsupervised learning from EEG data for epilepsy: A systematic literature review. Artif Intell Med 2025; 162: 103095.
  96. Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. Lancet 2019; 393: 689-701.
  97. Thom M. Review: Hippocampal sclerosis in epilepsy: a neuropathology review. Neuropathol Appl Neurobiol 2014; 40: 520-543.
  98. Tonelli MR, Callahan TC. Why alternative medicine cannot be evidence-based. Acad Med 2001; 76: 1213-1220.
  99. Traub-Weidinger T, Arbizu J, Barthel H, Boellaard R, Borgwardt L, Brendel M, Cecchin D, Chassoux F, Fraioli F, Garibotto V, Guedj E, Hammers A, Law I, Morbelli S, Tolboom N, Van Weehaeghe D, Verger A, Van Paesschen W, von Oertzen TJ, Zucchetta P, Semah F. EANM practice guidelines for an appropriate use of PET and SPECT for patients with epilepsy. Eur J Nucl Med Mol Imaging 2024; 51: 1891-1908.
  100. 100.Uchitel J, Lui A, Knowles J, Parker JJ, Phillips HW, Halpern CH, Grant GA, Buch VP, Hyslop A, Kumar KK. Intracranial neuromodulation for pediatric drug-resistant epilepsy: early institutional experience. Front Surg 2025; 12: 1569360.
  101. 101.Vergonjeanne M, Auditeau E, Erazo D, Luna J, Gelle T, Gbessemehlan A, Boumediene F, Preux PM; QUINET Collaboration. Epidemiology of epilepsy in low- and middle-income countries: experience of a standardized questionnaire over the past two decades. Neuroepidemiology 2021; 55: 369-380.
  102. 102.Wagner-Gutiérrez N, Gonzalez SA, Rubio MA, Sánchez-Franco S, Palencia-Pérez L, Blanco M, Adlakha D, Aguirre-Patiño JS, Ossa N, Vietto G, Suárez D, Sarmiento OL. Quality of life, mental health and social relationships among older adults participating in the Recreovía physical activity community program. Int J Equity Health 2025; 24: 145.
  103. 103.Wang G, Jing L, Wang Y, Mehmood A, Zhang H, Guo R, Zhang L, Li B. Interferon regulatory factor 5 gene polymorphisms and mRNA expression levels are associated with neuromyelitis optica spectrum disorder. Mol Neurobiol 2024; 61: 7989-7999.
  104. 104.Wenqi Y, Lingxi W, Mehmood A, Shah W. Nanotechnology-enabled therapies improve blood-brain barrier challenges in brain tumor. Int J Polym Mater 2023; 73: 1429-1450.
  105. 105.Xi X, Mehmood A, Niu P, Yang J, Wang Y, Zhou H, Han X, Ma L, Jin S, Wu Y. Association of X-linked TLR-7 gene polymorphism with the risk of knee osteoarthritis: a case-control study. Sci Rep 2022; 12: 7243.
  106. 106.Yacubian EMT, Kakooza-Mwesige A, Singh G, Carpio A, de Figueiredo NV, Lutzky Saute R, Marques de Haes T. Common infectious and parasitic diseases as a cause of seizures: geographic distribution and contribution to the burden of epilepsy. Epileptic Disord 2022; 24: 994-1019.
  107. 107.Yin BW, Li B, Mehmood A, Yuan C, Song S, Guo RY, Zhang L, Ma T, Guo L. BLK polymorphisms and expression level in neuromyelitis optica spectrum disorder. CNS Neurosci Ther 2021; 27: 1549-1560.
  108. 108.Zeng X, Zhang K, Liang M, Yu B, Zhang P, Mehmood A, Zhang H. NAD+ affects differentially expressed genes-MBOAT2-SLC25A21-SOX6 in experimental autoimmune encephalomyelitis model. Int J Neurosci 2025; 135: 618-625.
  109. 109.Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshé SL, Nabbout R. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia 2022; 63: 1349-1397.
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