Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus

Berenika Olszewska; Anton Żawrocki; Jolanta Gleń; Joanna Lakomy; Joanna Karczewska; Monika Zabłotna; Marta Malek; Jerzy Jankau; Magdalena Lange; Wojciech Biernat; Roman Nowicki; Małgorzata Sokołowska-Wojdyło

doi:10.5114/ada.2020.100824

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus

Berenika Olszewska

¹

,

Anton Żawrocki

²

,

Jolanta Gleń

¹

,

Joanna Lakomy

²

,

Joanna Karczewska

²

,

Monika Zabłotna

¹

,

Marta Malek

¹

,

Jerzy Jankau

³

,

Magdalena Lange

¹

,

Wojciech Biernat

²

,

Roman J. Nowicki

¹

,

Małgorzata Sokołowska-Wojdyło

¹

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland

Department of Pathology, Medical University of Gdansk, Gdansk, Poland

Department of Plastic Surgery, Medical University of Gdansk, Gdansk, Poland

Adv Dermatol Allergol 2022; XXXIX (1): 81-87

DOI: https://doi.org/10.5114/ada.2020.100824

Online publish date: 2020/11/13

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AMA

Olszewska B, Żawrocki A, Gleń J, et al. Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(1):81-87. doi:10.5114/ada.2020.100824.

APA

Olszewska, B., Żawrocki, A., Gleń, J., Lakomy, J., Karczewska, J.,  & Zabłotna, M. et al. (2022). Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(1), 81-87. https://doi.org/10.5114/ada.2020.100824

Chicago

Olszewska, Berenika, Anton Żawrocki, Jolanta Gleń, Joanna Lakomy, Joanna Karczewska, Monika Zabłotna,  and Marta Malek et al. 2022. "Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39 (1): 81-87. doi:10.5114/ada.2020.100824.

Harvard

Olszewska, B., Żawrocki, A., Gleń, J., Lakomy, J., Karczewska, J., Zabłotna, M., Malek, M., Jankau, J., Lange, M., Biernat, W., Nowicki, R.,  and Sokołowska-Wojdyło, M. (2022). Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(1), pp.81-87. https://doi.org/10.5114/ada.2020.100824

MLA

Olszewska, Berenika et al. "Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 39, no. 1, 2022, pp. 81-87. doi:10.5114/ada.2020.100824.

Vancouver

Olszewska B, Żawrocki A, Gleń J, Lakomy J, Karczewska J, Zabłotna M et al. Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(1):81-87. doi:10.5114/ada.2020.100824.

Introduction
Cutaneous T-cell lymphomas (CTCL) are malignant lymphoproliferative disorders accompanied by persistent pruritus. Pruritogenic role of interleukin-31 (IL-31) has been studied extensively and was proven in atopic dermatitis (AD), while its role in CTCL is still rather vague.

Aim
To investigate IL-31 serum level along with IL-31, IL-31 receptor a (IL-31RA) and oncostatin M receptor b (OSMR) skin expression in CTCL and compare it to controls: AD and healthy volunteers.

Material and methods
The level of IL-31 in serum was measured using ELISA, while IL-31 and receptors’ expression in the skin were measured using immunohistochemistry and correlated with the stage of disease and pruritus severity.

Results
Expression of IL-31 and IL-31 receptor in serum and skin were significantly higher in CTCL and AD in comparison to healthy controls. No significant correlation between the IL-31 serum level and pruritus severity in CTCL patients was found. There was also no correlation between IL-31/IL-31RA/OSMR expression in the skin and CTCL pruritus, while IL-31 and IL-31RA in CTCL skin negatively correlated with the stage of disease.

Conclusions
Our data indicate that IL-31 does not play a crucial role in pruritus in CTCL but it is rather involved in the pathogenesis of the disease. It seems that IL-31 plays an essential role in the pruritus pathomechanism that is unique to AD.

keywords:

Interleukin-31 is overexpressed in skin and serum in cutaneous T-cell lymphomas but does not correlate to pruritus

Berenika Olszewska 1 , Anton Żawrocki 2 , Jolanta Gleń 1 , Joanna Lakomy 2 , Joanna Karczewska 2 , Monika Zabłotna 1 , Marta Malek 1 , Jerzy Jankau 3 , Magdalena Lange 1 , Wojciech Biernat 2 , Roman J. Nowicki 1 , Małgorzata Sokołowska-Wojdyło 1

cutaneous T-cell lymphomas, interleukin-31, oncostatin M receptor b, IL-31RA, pruritus, atopic dermatitis

Berenika Olszewska

¹

,

Anton Żawrocki

²

,

Jolanta Gleń

¹

,

Joanna Lakomy

²

,

Joanna Karczewska

²

,

Monika Zabłotna

¹

,

Marta Malek

¹

,

Jerzy Jankau

³

,

Magdalena Lange

¹

,

Wojciech Biernat

²

,

Roman J. Nowicki

¹

,

Małgorzata Sokołowska-Wojdyło

¹