en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank


 
1/2009
vol. 47
 
Share:
Share:
more
 
 
abstract:
Review paper

Interleukin 6 – biological activities and role in rheumatoid arthritis pathogenesis

Ewa Kontny
,
Włodzimierz Maśliński

Reumatologia 2009; 47, 1: 24-33
Online publish date: 2009/04/01
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Interleukin 6 (IL-6) is a pleiotropic cytokine exerting multidirectional effects on the cells of both innate and acquired immune systems. This cytokine is recognized as a key factor regulating the defence mechanisms of organisms. Its ability to initiate and regulate acute inflammation as well as to facilitate and direct an acquired immune response are the major functions of this cytokine. Interleukin 6 also exerts systemic effects. Overproduction of IL-6 mediates a shift from acute to chronic inflammation and is critical for the development of some diseases. The structure of IL-6 and its receptors, the signal transduction pathways and biological activities, as well as the implications of this cytokine in animal models of both arthritis and rheumatoid arthritis (RA) are reviewed. Currently available data show that IL-6 blockade will be a useful therapeutic strategy for RA patients and has scientific support.
keywords:

interleukin 6, biological activities, rheumatoid arthritis







Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.