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2/2011
vol. 113 abstract:
Original paper
Interleukin 8 and interferon gamma in ocular toxoplasmosis
Jacek Czepiel
1
,
Grażyna Biesiada
1
,
Iwona Sobczyk-Krupiarz
1
,
Grażyna Miklaszewska
2
,
Danuta Fedak
3
,
Bogdan Solnica
3
,
Tomasz Mach
1
,
Aleksander Garlicki
1
Klinika Oczna 2011, 113 (2): 149-152
Online publish date: 2011/06/29
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Introduction
Toxoplasmosis is one of the most common parasitic infections in the world, it is caused by Toxoplasma gondii. The infection is typically asymptomatic or the symptoms are very mild. Approximately 10% patients have limphadenopathy, involvement of the others organs, like eyes, nervous system, liver, heart, are observed more rarely. The aim of our study was to assess the level of selected cytokines in blood among patients with ocular toxoplasmosis. Material and methods We have enrolled in the study 30 patients, 19-42 years old, treated for ocular toxoplasmosis, and 20 healthy volunteers, 20-48 years old, to the control group. Tests for blood morphology, C-reactive protein, the level of IL-8 and IFN-γ were performed in all patients. The blood parameters in toxoplasmosis group were performed before antiparasitic treatment was given. Results The level of IFN-γ in blood was lower among patients with ocular toxoplasmosis comparing with control group (1,52 vs 4,18 pg/ml; p = 0,002). The level of IL-8 in blood was lower among patients with ocular toxoplasmosis comparing with control group (22,96 vs 94,3 pg/ml; p = 0,007). There were no correlations between analyzed cytokines and blood morphology or CRP. Conclusions The low level of IFN-γ and IL-8 in blood is important factor leading to reactivation of the ocular toxoplasmosis. keywords:
toxoplasmosis, cytokines, pathogenesis |
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POLSKI
