eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
2/2018
vol. 69
 
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abstract:

Intraoral manifestation of systemic AL amyloidosis with unique microscopic presentation of intracellular amyloid deposition in striated muscles

Zuzanna Oruba, Tomasz Kaczmarzyk, Katarzyna Urbańczyk, Artur Jurczyszyn, Szymon Fornagiel, Krystyna Gałązka, Anna Bednarczyk, Maria Chomyszyn-Gajewska

Pol J Pathol 2018; 69 (2): 200-204
Online publish date: 2018/07/06
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We report the history of a 59-year old patient with systemic AL amyloidosis of intraoral manifestation. The patient first presented with complaints about dysphagia and remarkable enlargement of the tongue with highly reduced mobility, as well as bilateral submucosal thickenings on the cheeks. Histopathological examination of the incisional biopsy of the buccal mucosa and underlying tissues revealed AL amyloidosis. The microscopic presentation was, however, unique, as the amyloid deposits were present intracellularly in the striated muscles. The subsequent bone marrow biopsy confirmed the diagnosis of primary amyloidosis/multiple myeloma – associated amyloidosis.
keywords:

AL amyloidosis, amyloid, multiple myeloma, macroglossia, oral manifestation

references:
Nandapalan V, Jones TM, Morar P, et al. Localized amyloidosis of the parotid gland: a case report and review of the localized amyloidosis of the head and neck. Head Neck 1998; 20: 73-78.
Sipe JD, Benson MD, Buxbaum JN, et al. Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines. Amyloid 2016; 23: 209-213.
Gouvea AF, Ribeiro AC, Leon JE, et al. Head and neck amyloidosis: clinicopathological features and immunohistochemical analysis of 14 cases. J Oral Pathol Med 2012; 41: 178-185.
Matsuo FS, Barbosa de Paulo LF, et al. Involvement of oral tissues by AL amyloidosis: a literature review and report of eight new cases. Clin Oral Investig 2016; 20: 1913-1920.
Elad S, Czerninski R, Fischman S, et al. Exceptional oral manifestations of amyloid light chain protein (AL) systemic amyloidosis. Amyloid 2010; 17: 27-31.
Cohen AD, Comenzo RL. Systemic light-chain amyloidosis: advances in diagnosis, prognosis, and therapy. Hematology Am Soc Hematol Educ Program 2010; 2010: 287.
van der Waal RI, van de Scheur MR, Huijgens PC, et al. Amyloidosis of the tongue as a paraneoplastic marker of plasma cell dyscrasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 444-447.
Chapin JE, Kornfeld M, Harris A. Amyloid myopathy: characteristic features of a still underdiagnosed disease. Muscle Nerve 2005; 31: 266-272.
Prashantha DK, Taly AB, Sinha S, et al. Familial amyloidotic polyneuropathy with muscle, vitreous, leptomeningeal, and cardiac involvement: phenotypic, pathological, and MRI description. Ann Indian Acad Neurol 2010; 13: 142-144.
Prayson RA. Amyloid myopathy: clinicopathologic study of 16 cases. Hum Pathol 1998; 29: 463-468.
Röcken C, Sletten K. Amyloid in surgical pathology. Virchows Arch 2003; 443: 3-16.
Spuler S, Emslie-Smith A, Engel AG. Amyloid myopathy: an underdiagnosed entity. Ann Neurol 1998; 43: 719-728.
Tuomaala H, Kärppä M, Tuominen H, et al. Amyloid myopathy: a diagnostic challenge. Neurol Int 2009; 1: e7.
Kyle RA, Bayrd ED. Amyloidosis: review of 236 cases. Medicine (Baltimore) 1975; 54: 271-299.
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